grant
Dynamic Interactions of the Ovarian-Fallopian Axis in High Grade Serous Ovarian Cancer
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 10 Jul 2019Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-D print3-D printer3-Dimensional3D3D Print3D cell culture3D culture3D printer3D printing53BP1AdhesionsAgarAgeAnatomic SitesAnatomic structuresAnatomyBiologic ModelsBiologicalBiological ModelsBody SystemBody TissuesBreast FeedingBreast fedBreastfedBreastfeedingCD44CD44 geneCancer CauseCancer EtiologyCancer InductionCancersCarcinomaCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCessation of lifeClinicalCollaborationsCopy Number PolymorphismDNA DamageDNA InjuryDataDeathDetectionDevelopmentDevicesDiseaseDisorderEndocrine Gland SecretionEngineeringEpithelial CellsEpithelial cancerEpitheliumExposure toFallopian Tube CancerFallopian Tube NeoplasmsFallopian Tube TumorFallopian TubesFemale Genital SystemFemale Reproductive CancerGestationGrantGynecologic CancerGynecological CancerHG38HeterograftHeterologous TransplantationHormonesHumanIGF2IGF2 geneIntracellular Communication and SignalingInvadedLGR5LGR5 geneLactationLesionLocationMDU3MMAC1MMAC1 proteinMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Female Reproductive System NeoplasmMalignant Gynecologic NeoplasmMalignant Gynecologic TumorMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the Female Reproductive SystemMalignant Tumor of the OvaryMalignant fallopian tube tumorMalignant neoplasm of fallopian tubeMalignant neoplasm of ovaryMammalian OviductsMeasuresMenarcheMenstrual cycleMetastasisMetastasis to OvaryMetastasizeMetastatic LesionMetastatic Malignant Neoplasm to the OvaryMetastatic Malignant Tumor to the OvaryMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMicrofluidicsModel SystemModelingModern ManMonitorMurineMusMutated in Multiple Advanced Cancers 1NamesNeoplasm MetastasisOral ContraceptivesOrgan SystemOrganoidsOvarianOvarian MetastasisOvaryOvary CancerOvulationPHTS genePHTS proteinPTENPTEN genePTEN proteinPTEN1PaperPathway interactionsPenetrationPgp1Phosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10Predictive FactorPregnancyPreventative strategyPreventionPrevention strategyPreventive strategyProcessProliferatingProtein SecretionProteinsProteomicsPublishingRepressionResearch SupportRisk FactorsRisk ReductionRoleSalpinxSecondary NeoplasmSecondary TumorSecretory CellSerousSignal TransductionSignal Transduction SystemsSignalingSiteSourceStem Cell likeStrains Cell LinesStromal CellsStructureSurfaceSurvival RateSystemTP53BP1TechnologyTestingTherapeutic HormoneTimeTissuesTumor CellTumor Cell MigrationTumor Suppressor ProteinsUterine TubesWNT4WNT4 geneWingless-Type MMTV Integration Site Family, Member 4Women's mortalityXenograftXenograft procedureXenotransplantationagesbio-printingbiologicbiological signal transductionbioprintingbirth control pillblocking factorcancer diagnosiscancer metastasiscancer progenitorcancer progenitor cellscancer stem cellcancer stem like cellcarcinogenesiscopy number variantcopy number variationcorpus luteumcultured cell linedeath among femalesdeath among womendeath in femalesdeath in womendeath rate among womendeath rate in womendevelopmentalepithelial carcinomafemale deathfemale genital tractfemale mortalityfemale reproductive body systemfemale reproductive organ systemfemale reproductive systemfemale reproductive tractfimbriagynecologic body systemgynecologic malignancygynecologic organ systemgynecological malignancyhigh riskhuman tissueiPSiPSCiPSCsimprovedin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinnovateinnovationinnovativelactatinglactationalmalignancymalignant progenitormalignant stem cellmigrationmortality among femalesmortality among womenmortality in femalesmortality in womenmutated in multiple advanced cancers 1 proteinnamenamednamingneoplasm/cancerneoplasticneoplastic cellnoveloncogenic progenitoroncogenic stem cellsorgan chiporgan on a chiporgan on chipovarian canceroviductp202p53-binding protein 1p53BP1pathwayphosphatase and tensin homologue on chromosome tenpreventpreventingprogenitor capacityprogenitor cell likeprogenitor cell markersprogenitor cell nicheprogenitor cell poolprogenitor cell populationprogenitor like cancer cellprogenitor markersprogenitor nicheprogenitor poolprogenitor populationprogenitor stem cell markersprogenitor-likereduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskreplication stressreproductiveresponserisk-reducingsmall moleculesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspheroidsstem and progenitor cell nichestem and progenitor cell populationstem cell biomarkersstem cell characteristicsstem cell markersstem cell nichestem cell poolstem cell populationstem like cancer cellstem-likestemnessthree dimensionalthree dimensional cell culturethree dimensional printingtreatment strategytumortumor cell metastasistumor initiationtumor suppressortumorigenicversicanwomen's deathwomen's death ratewomen's genital tractwomen's reproductive tractxeno-transplantxeno-transplantationµfluidic
Description preview
Ovarian cancer is the most lethal cancer of the female reproductive system, with over 21,000 new ovarian
cancer diagnoses and 14,000 deaths annually in the US. The total lifetime number of ovulations is a key risk
factor for developing ovarian cancer. Factors that repress ovulation reduce the risk of ovarian cancer, such as
oral contraceptives,…
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