grant

Duke Center for HIV Structural Biology

Organization DUKE UNIVERSITYLocation DURHAM, UNITED STATESPosted 14 Jun 2022Deadline 31 Mar 2027
NIHUS FederalResearch GrantFY2026AIDSAIDS VirusAIDS preventionAIDS/HIVAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAdherenceAdvanced HIVAntibodiesAntigen Binding FragmentAntigenic DeterminantsAutologousB blood cellsB cellB cell receptorB cellsB-Cell ActivationB-Cell Antigen ReceptorB-Cell Receptor BindingB-CellsB-LymphocytesB-cellBehaviorBindingBinding DeterminantsBiologic SciencesBiological SciencesBiologyBioscienceBlocking AntibodiesCell BodyCell Communication and SignalingCell SignalingCell membraneCellsChronic DiseaseChronic IllnessClinicalClonal ExpansionCollaborationsComplexCurriculumCytoplasmic MembraneDevelopmentDiseaseDisease remissionDisorderEconomic BurdenEducational CurriculumEducational workshopElementsEnv trimerEnvelope ProteinEnvironmentEpitopesEye SocketFab FragmentsFab ImmunoglobulinsFosteringFutureGlycoproteinsGoalsGrantHIVHIV EnvHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV InfectionsHIV PreventionHIV env Protein gp120HIV envelopeHIV envelope proteinHIV glycoprotein EnvHIV individualsHIV infected individualsHIV infected personsHIV peopleHIV positive individualsHIV positive peopleHIV vaccinatedHIV vaccinationHIV viral infectionHIV virus infectionHIV-1HIV-1 EnvHIV-1 envelopeHIV-1 glycoprotein EnvHIV-1 infectionHIV-1 preventionHIV-1 vaccinationHIV-IHIV/AIDSHIV/AIDS preventionHIV1HTLV-III gp120HumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Ig Somatic HypermutationImmuneImmune Cell ActivationImmune responseImmunesImmunobiologyImmunoglobulin Somatic HypermutationImmunoglobulin, F(ab) FragmentImmunologyImmunophysiologyInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1InstitutionIntracellular Communication and SignalingInvestigatorsJournalsKineticsKnowledgeLAV-HTLV-IIILife SciencesLymphadenopathy-Associated VirusMagazineMediatingMembraneMentorsMethodsMicrobiologyModern ManMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMovementNational Institutes of HealthOcular orbitOrbital CavityOutcomePLWHPWHPathway interactionsPeptidesPersonsPlasma MembranePlayPostdocPostdoctoral FellowPrevent HIVProcessProvirusesReceptor ActivationReceptor ProteinReceptor SignalingRemissionResearchResearch AssociateResearch PersonnelResearch ResourcesResearchersResourcesRoleScientistSeriesSevere HIV DiseaseSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpecificityStructureStudentsStudy SectionSurfaceTechniquesTechnologyTexasTherapeuticTimeTrainingTraining ActivityTraining ProgramsUnited States National Institutes of HealthUniversitiesVaccinesViralViral reservoirViremiaVirusVirus reservoirVirus-HIVVisualizationWorkWorkshopWritingactivated B cellsantiretroviral therapyantiretroviral treatmentatomic interactionsbiological signal transductionbody movementcareerchronic disorderconformationconformationalconformational stateconformationallyconformationsdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalenv Antigensenv Gene Productsenv Glycoproteinsenv Polyproteinsenv Proteinglobal healthgp120gp120 ENV Glycoproteingp120(HIV)high definitionhigh-resolutionhost responsehuman immunodeficiency virus infectionimmune activationimmune system responseimmunoresponseindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinnovateinnovationinnovativeinsightinterestknowledgebaselatent HIV reservoirlatent HIV-1 reservoirlatent HIV1 reservoirlesson plansmembrane structuremethods to study multiple-level influencesmolecular dynamicsmulti-level analysismulti-level modelmultilevel analysismultilevel modelmultilevel modelingneutralizing antibodynew drug targetnew druggable targetnew pharmacotherapy targetnew technologynew therapeutic targetnew therapy targetnext generationnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel technologiesnovel therapeutic targetnovel therapy targetorbitpandemicpandemic diseasepathwaypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency virusplasmalemmapost-docpost-doctoralpost-doctoral traineeprevent AIDSprevent human immunodeficiency virusprogramsreceptorreceptor bindingreceptor boundresearch associatesresistance mechanismresistant mechanismresponseskill acquisitionskill developmentsocial rolesomatic hypermutationspatial and temporalspatial temporalspatiotemporalstructural biologytemporal measurementtemporal resolutiontherapeutic targettime measurementtraining modulevaccination against HIVvaccination against HIV-1vaccination studyvaccination trialvaccination with HIVvaccine developmentvaccine responsevaccine responsivenessvaccine studyvaccine trialvaccine-induced responseviraemiaviral reboundviral sepsisvirus reboundvirusemia
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Full Description

Abstract
The Developmental Core will offer a collaborative and nurturing environment for training and mentoring of early career investigators who are in the structural biology field. This Core will serve both Center-affiliated and non-Center affiliated investigators with an interest in HIV-1 structural biology. The development of trainees into successful and independent scientific professionals will be fostered through customized curricula, mentoring activities, access to state-of-the-art technologies through workshops and training programs conducted by the three Scientific Cores of the Center. The Developmental Core will benefit from the existing training and mentoring environments at the participating institutions. These include the Duke Human Vaccine Institute Training and Mentoring Program (DTMP), the Duke CFAR Developmental Core, the Vanderbilt Program in Computational Microbiology and Immunology, the University of Texas Interdisciplinary Life Sciences Graduate Programs, NIH T32 training programs and other such training and mentoring programs. Through close networking with existing programs in the different partner institutions, we will augment our training resources to expand the orbit of the trainees beyond their own institutions. The goals of the Developmental Core are to expand trainees’ knowledgebase and confidence through the use of customized curricula and technology, and offer seminars, journal clubs, short courses, mock study sections, and grant writing workshops. Training development activities of the Center will include methods-focused workshops designed to leverage the expertise and strengths of each Scientific Core to facilitate cross-training and skill development of students, postdoctoral fellows and early career scientists. The Developmental Core will work closely with the Projects and Scientific Cores to identify training and skill development opportunities, as well as new technologies that will augment the existing scientific resources of the Center. These interactions will drive the development of training resources within the Center, at the same time fostering collaborations between labs. Mentoring activities of the Center, led by the Developmental Core, will contribute to the training of the next generation of HIV researchers, and will generate a rich compilation of workshops and training modules that will be made publicly available to assist in the development of similar programs in the future.

Grant Number: 5U54AI170752-05
NIH Institute/Center: NIH

Principal Investigator: Priyamvada Acharya

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