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DSPP signaling in dentinogenesis
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 1 Mar 2009Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025ATP-protein phosphotransferaseAcetylationAffectAnimal ModelAnimal Models and Related StudiesAreaArg-Gly-AspArginine-Glycine-Aspartic Acid Cell Adhesion DomainAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBioinformaticsBiologicalBiological FunctionBiological ProcessCLG4BCariesCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineCell LineageCell NucleusCell SignalingCell Surface ProteinsCell membraneCellLineChromatinCommunitiesComplexCytoplasmic MembraneDNA mutationDNA-Dependent RNA Polymerase IIDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDPP geneDPP proteinDSP geneDSP proteinDSPP geneDSSP geneDSSP proteinDataDefectDentalDental AttritionDental DecayDental PapillaDental PulpDental cariesDentinDentin DysplasiaDentin FormationDentin PhosphophorynDentin PhosphoproteinDentinogenesisDentinogenesis ImperfectaDentistryDentistsDentitionDevelopmentDiseaseDisorderEconomicsEsteroproteasesExhibitsExtracellular Matrix ProteinsFocal Adhesion Kinase 1FutureGELBGEM modelGEMM modelGene AlterationGene ExpressionGene MutationGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic DiseasesGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseGoalsHealthHereditaryHereditary DiseaseHistonesHistoryHomeostasisIn VitroInborn Genetic DiseasesIncidenceInheritedInherited disorderIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingKO miceKinase Family GeneKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLeannessLifeLigand BindingLigandsMMP9MMP9 geneMesenchymalMolecularMolecular InteractionMutationNIDCRNIDRNational Institute of Dental ResearchNational Institute of Dental and Craniofacial ResearchNational Institutes of HealthNatural regenerationNon-Polyadenylated RNANuclear ProteinNuclear TranslocationNucleusNull MouseOdontoblastsOutcomes ResearchPTK2 Protein Tyrosine Kinase 2PathogenesisPathway interactionsPeptidasesPeptide HydrolasesPersonal SatisfactionPersonsPhosphorylationPhysiological HomeostasisPlasma MembranePlayPopulationProcessProductivityProtease GeneProteasesProtein KinaseProtein PhosphorylationProteinasesProteinsProteolytic EnzymesPublishingPulp ChambersQOLQuality of lifeRGD (sequence)RGD Cell Adhesion DomainRGD DomainRGD MotifRGD Tripeptide SequenceRGD peptideRGD tripeptideRNARNA ExpressionRNA Gene ProductsRNA Polymerase BRNA Polymerase IIRNA PolymerasesReagentReceptor ProteinRecording of previous eventsRegenerationResearchRibonucleic AcidRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStrains Cell LinesSyndromeTestingThinnessTimeToothTooth AttritionTooth ComponentsTooth DiseasesTooth DisorderTooth structureTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesUnited States National Institutes of HealthUpregulationUse of New TechniquesWorkarginyl-glycyl-aspartic acidbeta(6) integrinbiologicbiological signal transductioncellular differentiationconditional knock-outconditional knockoutcultured cell linedental diseasedental disorderdentin sialophosphoproteindentin sialoproteindevelopmentaleconomicendogenous substrate pp120extracellularfocal adhesion kinasefocal adhesion protein tyrosine kinasefocal adhesion-associated protein tyrosine kinase pp125FAKgene defectgenetic conditiongenetic disordergenetically engineered mouse modelgenetically engineered murine modelgenome mutationglycogen synthase a kinasehereditary disorderheritable disorderhistorieshydroxyalkyl protein kinasein vivoinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderinnovateinnovationinnovativeintegrin beta6integrin β6mineralizationmodel of animalmouse modelmurine modelmutant allelenoveloccludinoverexpressoverexpressionpathwayphosphorylase b kinase kinaseplasmalemmaprogenitor cell differentiationprogenitor differentiationpulpreceptorrecruitregeneraterepairrepairedsocialsocial rolestem and progenitor differentiationstem cell differentiationteethtooth decaytooth weartranscription factorwell-beingwellbeing
Applications closed.
Description preview
Project summary
One of the most important goals of dentistry and the NIDCR/NIH is to generate a whole “Bio-
Tooth”. Dentin is a critical structural component of tooth. Although it has made great progress of
dentin development benefit for numerous hereditary syndromes and chromosomal anomalies,
many gaps have been remained. Understanding signaling…
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