grant
Drug Repurposing Screening for HIV and Other Viruses
Organization NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAIDSAIDS VirusAIDS/HIVAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAnti-Retroviral AgentsAnti-viral AgentsAssayBindingBioassayBiochemicalBiological AssayCOVID-19 infectionCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 virusCell BodyCell DeathCellsCessation of lifeChronicCirculatory CollapseClinicalClinical DataClinical TrialsCoV-2CoV2CollaborationsDataDeathDevelopmentDisease ManagementDisorder ManagementDoseDrug KineticsDrugsEligibilityEligibility DeterminationEnsureEpidemicFDA approvedFTIFarnesyl Transferase InhibitorFarnesyltransferase InhibitorsGS-5734GoalsHIVHIV/AIDSHealth Care SystemsHigh Throughput AssayHumanHuman Immunodeficiency VirusesImmuneImmunesIndividualInfectionLAV-HTLV-IIILibrariesLifeLife CycleLife Cycle StagesLonafarnibLymphadenopathy-Associated VirusMGF proteinMGSNF proteinMediatingMedicationMethodsModern ManMolecular InteractionNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesOutcomePathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPersonsPharmaceutical PreparationsPharmacodynamicsPharmacokineticsPreclinical dataProtein Farnesyltransferase InhibitorsProtocol ScreeningPublic HealthPulmonary PathologyQOL improvementR-Series Research ProjectsR01 MechanismR01 ProgramRegimenResearch GrantsResearch Project GrantsResearch ProjectsSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 infectionSARS-CoV-2 inhibitorSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2STAT5STAT5ASTAT5A geneSTAT5a Transcription FactorSafetySarasarSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 inhibitorSevere acute respiratory syndrome related corona virus 2ShockSignal Transducer and Activator of Transcription 5ASpecificityStat5 proteinStat5a proteinStat5alpha proteinToxic effectToxicitiesValidationVekluryViralViral DiseasesVirusVirus DiseasesVirus-HIVWorld Health OrganizationWuhan coronavirusanti-retroviralanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantiretroviral therapyantiretroviral treatmentblock SARS-CoV-2block severe acute respiratory syndrome coronavirus 2circulatory shockcoronavirus disease 2019 infectioncoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease-19 virusdetermine efficacydevelopmentaldrug candidatedrug developmentdrug repositioningdrug repurposingdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationepidemic containmentepidemic controlepidemic mitigationepidemic responseevaluate efficacyexamine efficacyglobal healthhCoV19high throughput screeninghumanized micehumanized mouseimprovedimprovements in QOLimprovements in quality of lifein vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2inhibit SARS-CoV-2inhibit severe acute respiratory syndrome coronavirus 2insightknowledge baselatency/reactivationlatent HIV reservoirlatent HIV-1 reservoirlatent HIV1 reservoirlife courselung pathologymammary gland factormammary gland-specific nuclear factornCoV2necrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnirmatrelvirnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoutbreak concernoutbreak potentialoutbreak riskoutbreak threatpathwaypatient oriented outcomespre-clinicalpre-clinical evaluationpreclinicalpreclinical evaluationpreclinical findingspreclinical informationpreventpreventingquality of life improvementreactivation from latencyremdesivirrepurposing agentrepurposing medicationscreeningscreeningssevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainsshockssignal tranducer and activator of transcription 5small moleculesynergismtherapeutic candidatevalidationsviral infectionvirus infectionvirus-induced disease
Description preview
HIV Latency-Reversing Agent Screening. Human immunodeficiency virus (HIV) has caused more than 35 million deaths worldwide. Management of the disease requires the daily administration of a combination of antiretroviral (ART) drugs for the life of the infected individual. This is due to the presence of an intact and inducible latent reservoir of…
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