grant
Dopaminergic modulation of NMDA receptor signaling in the Nucleus Accumbens
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20252-photon3'5'-cyclic ester of AMPAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)AttenuatedBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsChronicCorpus StriatumCorpus striatum structureCyclic AMPCyclic AMP-Dependent Protein KinasesD1 receptorD2 receptorDA NeuronDRD2 ReceptorDecision MakingDendritesDendritic SpinesDopamineDopamine D1 ReceptorDopamine D2 ReceptorDopamine ReceptorDopamine neuronDrug IontophoresisDrug TherapyDrug usageDysfunctionElectrophysiologyElectrophysiology (science)EncephalonEquilibriumExposure toFrequenciesFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGPCRGTP-Binding ProteinsGTP-Regulatory ProteinsGeneticGlutamate ReceptorGlutamatesGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHydroxytyramineImageInjectionsIntracellular Communication and SignalingInvestigationIontophoresisKinasesL-GlutamateLearningMedialMediatingMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureMotivationMurineMusN Methyl D aspartic AcidN methyl D aspartateN-Methyl-D-Aspartate ReceptorsN-Methyl-D-aspartateN-MethylaspartateN-Methylaspartate ReceptorsNMDANMDA Receptor-Ionophore ComplexNMDA ReceptorsNatureNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensPKAPharmacological TreatmentPharmacologyPharmacotherapyPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPhysiopathologyPlayPrefrontal CortexProtein Kinase AProteinsReceptor ProteinReceptor SignalingRegulationRewardsRhodopsinRoleSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSliceSpecificitySpinal ColumnSpineStriate BodyStriatumSubstance Use DisorderSynapsesSynapticSynaptic plasticitySystemTestingThalamic structureThalamusTransgenic MiceTransmissionTransphosphorylasesVentral StriatumVertebral columnViralVisual PurpleWorkabused drugabused drugsaddictionaddictive disorderadenosine 3'5' monophosphatearrestin Battenuateattenuatesbackbonebalancebalance functionbeta-arrestinbiological signal transductioncAMPcAMP-Dependent Protein Kinasesdendrite spinedimerdopaminergic neurondrug abuseddrug interventiondrug of abusedrug treatmentdrug usedrugs abuseddrugs of abuseelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalingimagingiontophoresis therapyneurological diseaseneuronalneuronal excitabilityoptogeneticspatch clamppathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspostsynapticpresynapticpreventpreventingreceptorsocial rolestriatalsubstance use and disordersynapsethalamictransmission processtwo-photonβ-arrestin
Description preview
Project Summary
Alterations in both dopamine (DA) and glutamate signaling in the Nucleus Accumbens (NAc) are thought to play
a key role in substance use disorders and addiction. DA regulates NAc circuit activity by modulating glutamatergic
transmission and receptor activity, however, the precise mechanisms remain unclear. Synaptic plasticity and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click