grant
Dopaminergic Gut-Brain Signaling on Adolescent Reward Learning After Adversity: Toward New, Noninvasive Treatments for Depression and Anxiety
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 8 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202512-20 years oldAccelerationAcetatesAdolescenceAdolescentAdolescent YouthAgeAmericanAmidesAnimalsAnxietyAnxiety DisordersAromatic Amino AcidsAutomobile DrivingBehaviorBlood PlasmaBlood SampleBlood specimenBody TissuesBrainBrain Nervous SystemCell Communication and SignalingCell SignalingChild Abuse and NeglectChildhoodChildhood maltreatmentClinicalClostridiumCorpus StriatumCorpus striatum structureDataDecision MakingDevelopmentDiagnosisEcological impactEmotional DepressionEncephalonEnrollmentEnvironmental FactorEnvironmental ImpactEnvironmental Risk FactorFatty AcidsFe elementFecesFunctional MetagenomicsGI microbiomeGene ClusterGenesGoalsHigh PrevalenceHortega cellHumanIntracellular Communication and SignalingIronLearningLiteratureLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMajor Depressive DisorderMeasuresMediatingMediationMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMetagenomicsMicrogliaModern ManNMR ImagingNMR TomographyNegotiatingNegotiationNerve Impulse TransmissionNerve TransmissionNeural DevelopmentNeuronal TransmissionNuclear Magnetic Resonance ImagingOutcomePathway interactionsPeripheralPlasmaPlasma SerumPreventionProxyPsychopathologyPublic HealthResearchReticuloendothelial System, Serum, PlasmaRewardsRiskRisk BehaviorsRisky BehaviorShort-Chain Fatty AcidsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSubstantia NigraSubstantia nigra structureSystemTestingTimeTissuesTranslatingVentral Tegmental AreaVolatile Fatty AcidsZeugmatographyabnormal psychologyadolescence (12-20)agesanxiety symptomsanxious symptomat risk behavioraxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncare givingcaregivingchild maltreatmentclinical depressiondepressiondepression symptomdepressivedepressive symptomsdesigndesigningdevelopmentaldigestive tract microbiomedrivingeffective therapyeffective treatmentenrollenteric microbiomeenvironmental riskexperiencegastrointestinal microbiomegitter cellglia signalingglial signalinggut microbiomegut to brain axisgut-associated microbiomegut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalingindexinginnovateinnovationinnovativeinterestintestinal biomeintestinal microbiomejuvenilejuvenile humanlife spanlife-time risklifespanlifetime risklong-term studylongitudinal outcome studiesmajor depressionmajor depression disordermesogliametabolism measurementmetabolomicsmetabonomicsmicrobialmicrobiomemicrobiome interventionmicrobiome therapeuticsmicrobiome therapymicrobiome treatmentmicrobiome-based interventionmicrobiome-based therapeuticmicrobiome-based therapymicrobiome-based treatmentmicroglial cellmicrogliocytenerve signalingneuralneural circuitneural circuitryneural controlneural imagingneural regulationneural signalingneuro-imagingneurocircuitryneurodevelopmentneuroimagingneurological imagingneuromelaninneuromodulationneuromodulatoryneuronal signalingneuroregulationneurotransmissionnovelpathwaypediatricperivascular glial cellreward processingstoolstriatalsynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttheoriesventral tegmentum
Description preview
ABSTRACT
Approximately 2 in 10 American adolescents have experienced major depression in their lifespan, and 3 in 10
have experienced an anxiety disorder. Despite the clear
Grant Number: 5R01MH136259-02
NIH Institute/Center: NIH
Principal Investigator: Bridget…
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