grant
Dopamine D1-like receptor stimulation promotes HIV neuroimmune pathogenesis in iPSC-derived human cortical assembloids
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 27 Feb 2026Deadline 26 Feb 2030
NIHUS FederalResearch GrantFY2026AIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAgonistAreaAssayAutomobile DrivingB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BioassayBiological AssayBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain regionCNS Nervous SystemCRG-2CXCL10CXCL10 geneCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesCorpus StriatumCorpus striatum structureCytoplasmDataDendritesDisease ProgressionDopamineDopamine AgonistsDopamine ReceptorDopamine Receptor AgonistsDopaminergic AgonistsEncephalonEncephalon DiseasesExhibitsExperimental DesignsFutureGene TranscriptionGeneral PopulationGeneral PublicGenetic TranscriptionGliaGlial CellsGlutamatesHIVHIV InfectionsHIV anti-retroviralHIV associated neurological diseaseHIV associated neurological disorderHIV disease transmissionHIV individualsHIV infected individualsHIV infected personsHIV infection spreadHIV infection transmissionHIV peopleHIV positive individualsHIV positive peopleHIV replicationHIV spreadHIV transmissionHIV viral infectionHIV viral replicationHIV viral transmissionHIV virus infectionHIV-1 infectionHIV-1 replicationHIV-1 spreadHIV-1 transmissionHIV-1 viral replicationHIV-1 virus replicationHIV-1 virus transmissionHIV/AIDS transmissionHPGFHepatocyte-Stimulating FactorHortega cellHumanHuman Immunodeficiency Virus Type 1 transmissionHuman Immunodeficiency VirusesHybridoma Growth FactorHydroxytyramineIFI10IFN-beta 2IFNB2IL-6IL6 ProteinINP10IP-10Image AnalysesImage AnalysisImmune RegulatorsImmunoglobulin Enhancer-Binding ProteinImmunomodulationImmunomodulatorsIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammasomeInflammationInflammatoryInflammatory ResponseInterleukin-6Intracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersKineticsKolliker's reticulumL-GlutamateLAV-HTLV-IIILinkLymphadenopathy-Associated VirusMGI-2MOB-1MacrophageMediatingMicro-tubuleMicrogliaMicrotubulesModelingModern ManMolecularMyeloid CellsMyeloid Differentiation-Inducing ProteinMφNF-kBNF-kappa BNF-kappaBNFKBNerve CellsNerve DegenerationNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeuraxisNeurocyteNeurogliaNeuroglial CellsNeuroimmuneNeurologicNeurologicalNeuron DegenerationNeuronal TransmissionNeuronsNeuropathogenesisNon-Polyadenylated RNANon-neuronal cellNonneuronal cellNuclearNuclear Factor kappa BNuclear Transcription Factor NF-kBNuclear TranslocationOutcomePLWHPWHPathogenesisPathway interactionsPatientsPharmacologyPhysiciansPhysiologicPhysiologicalPlasmacytoma Growth FactorProcessProductionPublic HealthQuinpiroleRNARNA ExpressionRNA Gene ProductsReceptor ActivationReceptor ProteinReportingRibonucleic AcidRiskRoleSCYB10SKF 38393-ASKF 38393ASKF-38393SKF38393SamplingScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStaining methodStainsStriate BodyStriatumSubstance Use DisorderSynapsesSynapticSystemTestingTranscriptTranscriptionTranscription ActivationTranscription Factor NF-kBTranscriptional ActivationTranslationsViralViral BurdenViral DiseasesViral LoadViral Load resultVirus DiseasesVirus ReplicationVirus-HIVaddictionaddictive disorderantiretroviral therapyantiretroviral treatmentassembloidsaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncareerco-morbidco-morbiditycohortcomorbiditycytokinedensitydrivingexperimentexperimental researchexperimental studyexperimentsextracellulargIP-10gitter cellglia signalingglial signalingglutamatergichiPSChuman iPShuman iPSChuman immunodeficiency virus infectionhuman immunodeficiency virus replicationhuman immunodeficiency virus transmissionhuman immunodeficiency virus-1 replicationhuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimage evaluationimage interpretationimmune modulationimmune modulatorsimmune regulationimmunologic reactivity controlimmunomodulatoryimmunomodulatory moleculesimmunoneurologyimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimprovedindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfected with HIVinfected with human immunodeficiency virusinsightinterferon beta 2kappa B Enhancer Binding Proteinlongitudinal caremesogliamicroglial cellmicrogliocytemicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemnerve cementnerve signalingneural degenerationneural inflammationneural signalingneuro-AIDSneuro-HIVneuroAIDSneuroHIVneurodegenerationneurodegenerativeneurodegenerative phenotypeneurofilamentneuroimmunologyneuroinflammationneuroinflammatoryneurological degenerationneuronalneuronal degenerationneuronal signalingneurotransmissionnew approachesnovel approachesnovel strategiesnovel strategynuclear factor kappa betapathwaypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency virusperivascular glial cellpharmacologicreceptorresponsescRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolespread of human immunodeficiency virusstriatalsubstance misusesubstance usesubstance use and disordersubstance usingsynapsetherapeutic agent developmenttherapeutic developmenttranscriptomicstranslationviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus-induced disease
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Neurologic complications remain prevalent in nearly 50% of people with HIV (PWH) and persist despite viral
suppression with antiretroviral therapy (ART). Though the exact processes mediating HIV neuropathogenesis
are not well understood, co-morbidities such as substance use disorders (SUD), which are higher in PWH
compared to the general…
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