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Does age matter for the development of pathogenic T helper 2 resident memory cells in the lung?
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 22 Nov 2023Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAdoptive Cell TransfersAdoptive TransferAdultAdult HumanAffectAgeAge of OnsetAirway Hyper-responsivenessAllergensAllergic asthmaAllergic inflammationAnimal ModelAnimal Models and Related StudiesAssayAsthma in ChildrenB220BioassayBiological AssayBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD45Cell BodyCell Communication and SignalingCell SignalingCellsCharacteristicsChildChild YouthChildhoodChildhood AsthmaChildren (0-21)ChromatinClonal ExpansionCommunicationDendritic CellsDevelopmentDiseaseDisease ProgressionDisorderDopamineEffector CellEndowmentEnvironmentEpitheliumExpression SignatureExtrinsic asthmaFoundationsFutureGP180Gene Expression ProfileGenesGoalsGrantHeterogeneityHouse Dust MitesHousedust MitesHumanHydroxytyramineHyperplasiaHyperplasticImmuneImmune systemImmunesInflammationIntracellular Communication and SignalingLY5LabelLeadLifeLineage TracingLungLung ParenchymaLung Respiratory SystemLung TissueMHC ReceptorMaintenanceMajor Histocompatibility Complex ReceptorMediatingMediatorMemoryMiceMice MammalsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMucous body substanceMucusMurineMusNeonatalNervePTPRCPTPRC genePathogenicityPathway interactionsPatientsPb elementPediatric asthmaPeptidesPhasePhenotypePopulationPyroglyphidaeRecurrenceRecurrentResidenciesRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderRoleSalineSaline SolutionSamplingSignal TransductionSignal Transduction SystemsSignalingStructure of parenchyma of lungSurfaceSystemT cell receptor repertoire sequencingT cell receptor sequencingT memory cellT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT-cell receptor repertoireT200T4 CellsT4 LymphocytesTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTestingTissuesVeiled Cellsadaptive immunityadoptive cell therapyadoptive cellular therapyadult animaladulthoodage associatedage associated differenceage associated effectsage based differenceage correlatedage dependentage dependent differenceage dependent variationage differenceage effectage linkedage relatedage related differenceage related effectsage related variationage specificage specific differenceagesaging effectairway hyper-reactivityairway hyperactivityairway hyperreactivityairway hyperresponsivenessairway hypersensitivityalleviate symptomameliorating symptomasthma attackasthma exacerbationasthma modelasthmaticatopic asthmabiological signal transductioncell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingchronic airway diseasechronic inflammatory diseasechronic respiratory diseasedecrease symptomdevelopmentaldiffer by agedifference across agedifference in ageearly childhoodexacerbation in asthmaexacerbation prone asthmaexacerbation prone asthmaticexperienceextrinsic allergic asthmafewer symptomsgene expression patterngene expression signatureglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadimpact of ageinfluence of agekidslater in lifelater lifelung developmentmature animalmemory T lymphocytemodel of animalmolecular profilemolecular signaturemouse modelmucousmultiomicsmultiple omicsmurine modelneonatal miceneonatepanomicspathwaypediatricpost-natal developmentpostnatalpostnatal developmentprogramsreduce symptomsrelieves symptomsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesymptom alleviationsymptom reductionsymptom relieftherapeutic candidatetherapeutic targetthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptometreatment strategyvariation by ageyoungster
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PROJECT SUMMARY
Allergic asthma is a chronic inflammatory disease that often progresses from childhood to adulthood.
Approximately 8% of the world population suffer from allergic asthma, making it one of the most common
respiratory diseases. Allergic asthma is characterized by recurrent type 2 inflammation, mucus
hyperplasia, and airway…
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