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DNA ligase activities during base excision repair coordination

Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 15 Aug 2022Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY2025ArchitectureBase Excision RepairsBiochemicalCancersCell BodyCellsChemicalsCommunicationComplement 1Complement component C1Cryo-electron MicroscopyCryoelectron MicroscopyDNADNA Base Excision RepairDNA DamageDNA Damage RepairDNA InjuryDNA LigasesDNA PolymerasesDNA RepairDNA Repair GeneDNA lesionDNA ligase IDNA mutationDNA repair proteinDNA-Dependent DNA PolymerasesDNA-Directed DNA PolymeraseDeoxyribonucleic AcidDiseaseDisorderElectron CryomicroscopyEngineering / ArchitectureEnvironmental HazardsEnzyme GeneEnzymesExposure toFailureGenesGenetic ChangeGenetic defectGenetic mutationGenome InstabilityGenomic DNAGenomic InstabilityHumanImpairmentIndividualKnowledgeLaboratoriesLigaseLigase GeneMacromolecular Protein ComplexesMalignant NeoplasmsMalignant TumorModern ManModificationMolecularMultiprotein ComplexesMutationOutcomePathway interactionsPlayPolydeoxyribonucleotide LigasesPolydeoxyribonucleotide SynthetasesPositionPositioning AttributeProcessProteinsRepair ComplexResearchResolutionRoentgen RaysRoleScaffolding ProteinScientific Advances and AccomplishmentsSingle Crystal DiffractionSiteSynthetasesUnscheduled DNA SynthesisVariantVariationWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray Crystallographybasebasesbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescryo-EMcryoEMcryogenic electron microscopygDNAgenome mutationinterdisciplinary approachmalignancymultidisciplinary approachneoplasm/cancerpathwaypreventpreventingprogramsrepairrepair functionrepairedreparative functionresolutionsscaffoldscaffoldingscientific accomplishmentsscientific advancessealsocial rolestem

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Description preview

PROJECT SUMMARY
Base excision repair (BER) is a critical mechanism for preventing the mutagenic and lethal consequences of

DNA damage generated by endogenous reactive chemical species or exposure to environmental hazards. BER

is multi-step pathway that requires a tight coordination between the repair proteins. The downstream steps of

BER pathway…

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DNA ligase activities during base excision repair coordination — UNIVERSITY OF FLORIDA | UNITED STATES | Aug 2022 | Dev Procure