grant
DNA damage deficiency in prostate cancer: functional characterisation and treatment
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
Description preview
Sequencing profiling studies of prostate tumours have identified common alterations in genes involved in DNA damage response. Up to 10% of patients with aggressive disease show ATM loss. Clinically, tumours with defects in DNA repair
genes such as BRCA1/2 show exceptional responses to PARP inhibitors, while ATM mutant tumour response is variable.…
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