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DNA Damage and Immunogenicity in Ewing Sarcoma
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Apr 2021Deadline 26 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY202514-HydroxydaunomycinActivated LymphocyteAddressAdolescentAdolescent YouthAdriamycineAdvanced CancerAdvanced Malignant NeoplasmAgonistAnimal ModelAnimal Models and Related StudiesAntineoplastic ProtocolsAntitumor ResponseAreaAuthorshipAutomobile DrivingB7-H1BARD-1BARD1BARD1 geneBRCA1BRCA1 Associated RING Domain 1 ProteinBRCA1 Gene ProductBRCA1 ProteinBRCA1 geneBRCA1-Associated RING Domain 1BioinformaticsBone CancerBreast CancerBreast Cancer 1 GeneBreast Cancer 1 Gene ProductBreast Cancer Type 1 Susceptibility GeneBreast Cancer Type 1 Susceptibility ProteinBreast-Ovarian Cancer ProteinCD274CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancer BiologyCancer Treatment ProtocolsCancersCareer CounselingCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCareer GuidanceCell BodyCell Communication and SignalingCell SignalingCell Surface ProteinsCell modelCellsCellular biologyCellular modelCheckpoint inhibitorChildhood Cancer TreatmentChildhood CancersChimera ProteinChimeric ProteinsCo-cultureCocultivationCocultureCoculture TechniquesCombination immunotherapyCombined Modality TherapyCommittee MembersComplementComplement ProteinsComputer AnalysisCyclic GMPDNADNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA mutationDataDedicationsDefectDeoxyribonucleic AcidDevelopment PlansDiagnosisDoxorubicinDoxorubicinaEWS-FLI-1EWS-FLI1EWS-FLI1 fusion proteinEarly Onset Gene Breast Cancer 1Early Onset Protein Breast Cancer 1Educational AchievementEducational StatusEducational workshopEnvironmentEwing's Family of TumoursEwing's Sarcoma/Peripheral Primitive Neuroectodermal TumorEwing's TumorEwings sarcomaFeedbackFosteringFusion ProteinGene ActivationGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGerm LinesGerm-Line MutationGoalsGrantGrowthGuanosine Cyclic MonophosphateHereditary Breast Cancer 1Hereditary MutationHumanHydroxyl DaunorubicinHydroxyldaunorubicinIFN activationIRF-1IRF1IRF1 geneImmuneImmune checkpoint inhibitorImmune mediated therapyImmune responseImmunesImmunobiologyImmunologically Directed TherapyImmunologyImmunomodulationImmunophysiologyImmunotherapyImpairmentIn VitroIndividualInfiltrationInflammatoryInterferon ActivationInterferon Regulatory Factor 1Intracellular Communication and SignalingInvestigationInvestmentsK-AwardsK-Series Research Career ProgramsKnowledgeLaboratoriesLiteratureLocationMalignant Bone NeoplasmMalignant Breast NeoplasmMalignant CellMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Osseous NeoplasmMalignant Osseous TumorMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant Tumor of the BoneMalignant childhood cancerManuscriptsMediatingMentorsModern ManMultimodal TherapyMultimodal TreatmentMutationMyD32 proteinOccupational GuidanceOncogenicOsseous CancerPARP InhibitorPARP PolymerasePARP proteinPARP-1 inhibitorPARPiPARSPD-L1PDL-1Pathway interactionsPatientsPediatric Cancer TreatmentPediatric OncologistPediatric OncologyPhysiciansPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) PolymerasesPoly(ADP-ribose) polymerase 1 inhibitorPoly(ADPribose) PolymeraseProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1RNF53RadiationRegulationRelapseResearchResearch Career ProgramResearch SpecimenSamplingScienceScientistSeasonsSignal TransductionSignal Transduction SystemsSignalingSpecimenStimulator of Interferon GenesT cell infiltrationT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTechnical ExpertiseTechniquesTestingTissue GrowthTrainingTraining TechnicsTraining TechniqueTumor CellTumor Cell BiologyTumor-Infiltrating LymphocytesUniversitiesUnscheduled DNA SynthesisUpregulationVocational CounselingVocational GuidanceWomanWorkWorkshopanti-cancer researchanti-tumor immune responseanti-tumor responsebiological signal transductionbrca 1 genecGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcGMPcancer cellcancer immunologycancer in a childcancer in childrencancer researchcareercareer counselorcareer developmentcell biologycheck point immunotherapycheck point inhibitioncheck point inhibitor therapycheck point inhibitory therapycheck point therapycheckpoint immunotherapycheckpoint inhibitioncheckpoint inhibitor therapycheckpoint inhibitory therapycheckpoint therapychild with cancerchildhood malignancycombination therapycombinatorial immunotherapycombined modality treatmentcombined treatmentcomplementationcomputational analysescomputational analysiscomputer analysescyclic GMP-AMP synthase/STINGcytokinecytotoxic CD8 T cellscytotoxic CD8 T lymphocytedetermine efficacydrivingdual immunotherapyeducational levelefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexecutive coachinggene repairgenome mutationgerm-line defectgermline varianthomologous recombinationhost responsehumanized micehumanized mouseimmune check pointimmune check point inhibitionimmune check point inhibitorimmune check point therapyimmune checkpointimmune checkpoint inhibitionimmune checkpoint therapyimmune microenvironmentimmune modulationimmune regulationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmunecheckpointimmuno therapyimmunogenicityimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedin vivointerferon-stimulated gene factor 1juvenilejuvenile humanmalignancymalignant breast tumormeetingmeetingsmodel of animalmouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm immunologyneoplasm/cancerneoplastic cellnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespediatric cancerpediatric malignancypoly ADP polymerasepoly ADP ribose synthetasepre-clinicalpreclinicalprogrammed cell death ligand 1programmed cell death protein ligand 1programsprotein death-ligand 1recruitrepair functionreparative functionresponseskillstechnical skillsthymus derived lymphocytetraining achievementtraining leveltraining statustumortumor DNAtumor cell DNAtumor immune microenvironmenttumor immunologytumor-immune system interactionstumor-specific DNA
Applications closed.
Description preview
The goal of this career development award is for the applicant to expand her knowledge and technical expertise
in tumor immunology and bioinformatic analyses in order to apply these new skills to investigation of the
childhood cancer Ewing sarcoma. Relapsed Ewing sarcoma is nearly uniformly fatal, and thus new treatment
approaches are desperately…
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