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Disturbed Crosstalk between Cholesterol Homeostasis and Inflammation Resolution in NASH
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 May 2023Deadline 10 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025ALXRAddressAnabolismAttenuatedCell Communication and SignalingCell SignalingCholesterolCholesterol HomeostasisCirrhosisCirrhotic hepatocyteCirrhotic liver cellClinicalClinical TrialsDataData SetDiseaseDisorderDocosahexaenoateDocosahexaenoic AcidsDocosahexenoic AcidsDrug TherapyDrugsFDA approvedFPR2FPR2 geneFPRH1FPRL1FibrosisFormyl Peptide Receptor 2Formyl Peptide Receptor Homolog 1Formyl Peptide Receptor-Like 1GWA studyGWASGene TranscriptionGenetic TranscriptionHM63HepaticHepatic CellsHepatic Parenchymal CellHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHigh PrevalenceHumanHuman GenomeInfiltrationInflammationInflammatoryInterruptionIntracellular Communication and SignalingInvestigatorsKupffer CellsLDL CholesterolLDL Cholesterol LipoproteinsLDL ReceptorsLDLR geneLXA4RLinkLipoprotein LDL ReceptorsLipoxin A4 ReceptorLiverLiver CellsLiver Cells CarcinomaLiver FibrosisLow Density Lipoprotein CholesterolLow Density Lipoprotein ReceptorMacrophageMediatingMediatorMedicationMiceMice MammalsModern ManMolecularMorbidityMorbidity - disease rateMurineMusMφNASHObesity EpidemicPPAR alphaPPAR-αPPARalphaPPARαPathogenesisPathway interactionsPatientsPeroxisome Proliferator-Activated Receptor alphaPeroxisome Proliferator-Activated Receptor αPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPopulationPositionPositioning AttributePrevalencePrimary carcinoma of the liver cellsProcessProtein Binding DomainProtein Binding MotifProtein-Protein Interaction DomainPublic HealthPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinRegulationResearch PersonnelResearchersResolutionRoleSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismStellate Sinusoidal MacrophageStressTestingTherapeuticTranscriptionanalogattenuateattenuatesbeta-Lipoprotein Cholesterolbiological signal transductionbiosynthesiscell typecholesterol metabolismchronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disordercirrhoticcytokinedrug interventiondrug treatmentdrug/agentfibrotic livergenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyhepatic body systemhepatic fibrosishepatic organ systemhuman RNA sequencinghuman RNA-seqhuman whole genomein vivoinnovateinnovationinnovativeinsightliver carcinomaliver macrophagemortalitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnon-alcohol induced steatohepatitisnon-alcoholic steato-hepatitisnon-alcoholic steatohepatitisnonalcoholic steato-hepatitisnonalcoholic steatohepatitisnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingreceptorresolutionsresponsescRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle nucleotide variantsingle-cell RNA sequencingsocial roletherapeutic targettranscriptome sequencingtranscriptomic sequencinguptakewhole genome association analysiswhole genome association study
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Project Summary/Abstract
Non-alcoholic steatohepatitis (NASH) has emerged as the leading cause of chronic liver disease worldwide, with
liver fibrosis as the most important predictor of morbidity and mortality in NASH. However, due to the major gaps
in understanding the mechanisms of NASH progression, particularly fibrosis, there are no…
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