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Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches
Organization METHODIST HOSPITAL RESEARCH INSTITUTELocation HOUSTON, UNITED STATESPosted 30 Sept 2013Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025ADAM10 proteinAddressBindingBioinformaticsBiological FunctionBiological ProcessBladder CancerBladder CarcinomaBladder NeoplasmBladder TumorsBladder Urothelial CarcinomaC-terminalCRISPRCRISPR/Cas systemCallicreinCancersCarcinoma CellCategoriesCell BodyCell Communication and SignalingCell NucleusCell SignalingCell secretionCell-Extracellular MatrixCellsCellular SecretionCessation of lifeChIP SequencingChIP-seqChIPseqClinicalClustered Regularly Interspaced Short Palindromic RepeatsCollagenCollagen ReceptorsCommunicationConceptionsDNA BindingDNA Binding InteractionDNA boundDataDeathDiseaseDisease ManagementDisorderDisorder ManagementDistalECMEctopic ExpressionEsteroproteasesExtracellular MatrixFamilyFibroblastsFundingGenesGoalsImageIntracellular Communication and SignalingInvadedInvestigationKLK familyKLKsKallidinogenaseKalliginogenaseKallikreinsKinin-Forming EnzymeKininogenaseKnock-outKnockoutKnowledgeLeiomyocyteLigandsLuciferase ImmunologicLuciferasesLungLung Respiratory SystemMalignant Bladder NeoplasmMalignant CellMalignant Epithelial CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the BladderMalignant neoplasm of urinary bladderMediatingMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungModalityMolecular InteractionMutateN-terminalNH2-terminalNatureNeoplasm MetastasisNuclearNuclear TranslocationNucleusPatternPeptidasesPeptide HydrolasesPhenotypePhosphorylationPhosphorylation SitePilot ProjectsPlayPrimary NeoplasmPrimary TumorProcessProgression-Free SurvivalsPropertyProtease GeneProteasesProtein FragmentProtein PhosphorylationProteinasesProteinsProteolytic EnzymesReceptor ActivationReceptor ProteinReceptor SignalingRegulationRoleSH2 DomainsSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSiteSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSpecific qualifier valueSpecifiedSurvival RateTestingTherapeutic InterventionTumor CellTumor VolumeTyrosine PhosphorylationTyrosine Phosphorylation SiteUrinary Bladder CancerUrinary Bladder CarcinomaUrinary Bladder Malignant TumorUrinary Bladder NeoplasmUrinary Bladder Transitional Cell CarcinomaUrinary Bladder Tumorairway smooth musclebiological signal transductionbladder transitional cell carcinomacancer cellcancer metastasiscancer microenvironmentcancer typechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical translationclinically translatabledesigndesigninggamma secretasegamma secretase compleximagingin vivoinnovateinnovationinnovativeintervention therapykininogeninlead candidatelung metastasismalignancymetastasize to the lungmetastatic processmigrationneoplasm/cancerneoplastic cellnew approachesnotchnotch proteinnotch receptorsnovelnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionpharmacologicpilot studyprecision medicineprecision-based medicinepulmonary metastasisreceptorrespiratory smooth musclescaffoldscaffoldingsocial rolesrc Homology Region 2 Domainsuccesstherapeutic targettumortumor cell metastasistumor microenvironmenturinary bladder urothelial carcinomaγ-secretase
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Description preview
PROJECT SUMMARY
Metastatic progression of the primary tumor accounts for the majority of cancer deaths. While the initial steps of
the metastatic cascade are rather well defined, identification of targets to block this process remains a major
clinical challenge. Previous studies have elegantly investigated the mechanistic contribution of tumor…
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