grant
Distinct responses to hypoxia in striated muscle
Organization UNIVERSITY OF WYOMINGLocation LARAMIE, UNITED STATESPosted 1 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AcuteBody TissuesCell Communication and SignalingCell SignalingChronicHumanHuman FigureHuman bodyHypoxiaHypoxicIntracellular Communication and SignalingLeftMammalian CellMediatingModern ManMolecularMuscleMuscle CellsMuscle TissueMyocardiumMyocytesO elementO2 elementOutcomeOxygenOxygen DeficiencyPhysiologicPhysiologicalPhysiologySignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleStimulusStriated MusclesSystemTissuesTransgenic MiceVentricularVoluntary Musclebiological signal transductioncardiac musclecell typeheart musclehuman diseaseinterestmouse modelmurine modelmuscle metabolismmuscularnovelpublic health relevanceresponseskeletaltool
Description preview
PROJECT SUMMARY
The cellular response to hypoxia is highly conserved yet is strikingly different between mammalian cell types.
Even within striated muscle, which represents over 40% of human body mass, the response to hypoxia is
distinct between skeletal and cardiac muscles. Our group is interested in understanding how these striated
muscle cells…
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