grant
Dissecting the viral and host constraints that govern influenza virus antigenic evolution
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 1 Dec 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2025Acylneuraminyl hydrolaseAffectAmino AcidsAvidityBindingBody TissuesCell BodyCellsCessation of lifeCirculationClinical Treatment MoabDNA mutationDataDeathDevelopmentEconomic BurdenEnvironmentEquilibriumEvolutionFlu vaccinationFutureGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenotypeGlycoproteinsH1N1H1N1 VirusHemagglutininHerd ImmunityHumanHumoral ImmunitiesImmuneImmune responseImmunesIn VitroIndividualInfluenza AInfluenza A Virus, H1N1 SubtypeInfluenza A virusInfluenza VirusInfluenza Viruses Type AInfluenza immunizationInfluenza vaccinationInfluenzavirus AKnowledgeModern ManMolecularMolecular InteractionMonoclonal AntibodiesMutationN-Acetylneuraminic AcidsN-Acylneuraminate GlycohydrolasesNeuraminidaseOligosaccharide SialidaseOrthomyxovirus Type APathway interactionsPatternPhenotypePlayPopulationProcessProphylactic vaccination against influenzaProteinsPublic HealthRNA VirusesReceptor ProteinResistanceRoleSeasonsShapesSialic AcidsSialidaseTestingTissuesType A InfluenzaVaccinationVaccinesVariantVariationViralViral ActivityViral FunctionViral HemagglutininsViral PhysiologyVirusadaptive immunityaminoacidantibody-based immunitybalancebalance functionbasebasesdevelopmentalexo alpha sialidaseflu immunisationgenome mutationhost responseimmune system responseimmunization strategyimmunoresponseimprovedin vivoinfluenza virus vaccinationinfluenzavirusmAbsmolecular arraymonoclonal Absneutralizing antibodynext generationpathwaypolyclonal antibodypressurereceptorreceptor bindingreceptor boundresistantseasonal fluseasonal influenzasialic acid receptorsocial roletrendvaccination against influenzavaccination strategyviral fitness
Description preview
Abstract
Seasonal influenza A viruses (IAV) cause hundreds of thousands of deaths every year, despite widespread pre-
exposure and vaccination. IAV persists in the human population by continually evolving resistance to herd
immunity through a process known as antigenic drift. The evolutionary potential of RNA viruses like IAV is often
considered…
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