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Dissecting the roles of type 2 diabetes-associated variants and effector genes in islet endoplasmic reticulum stress response
Organization UNIVERSITY OF CONNECTICUT SCH OF MED/DNTLocation FARMINGTON, UNITED STATESPosted 15 Mar 2022Deadline 14 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3D5-IsothiocyanatofluoresceinANX5ANX5 GeneANXA5ANXA5 geneATAC sequencingATAC-seqATACseqAdult-Onset Diabetes MellitusAffectAnchorin CIIAnchorin CII GeneAnnexin A5 GeneAnnexin A5 ProteinAnnexin VAssayAssay for Transposase-Accessible Chromatin using sequencingB9 endocrine pancreasBand Shift Mobility AssayBandshift Mobility AssayBasal Transcription FactorBasal transcription factor genesBeta CellBindingBioassayBiochemicalBiological AssayBiological FunctionBiological ProcessBlood GlucoseBlood SugarBody TissuesBusiness-Friendly AtmosphereCBP-ICIS GeneCIS proteinCIS-1 GeneCIS-1 ProteinCISH ProteinCISH geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalphobindin ICas nuclease technologyCausalityCell BodyCell Communication and SignalingCell DeathCell FunctionCell NucleusCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCessation of lifeChemicalsChromatinClinical SkillsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColorCommunicationComplexCoupledCytokine Inducible SH2-Containing ProteinCytokine-Inducible Inhibitor of Signaling Type 1BCytokine-Inducible Inhibitor of Signaling Type 1B GeneCytokine-Inducible SH2-Containing Protein GeneDNA SequenceDataData AnalysesData AnalysisDeathDevelopment PlansDiseaseDisorderDysfunctionENX2ENX2 GeneER stressElectrophoretic Mobility Shift AssayEndocrine PancreasEndonexin IIEndonexin II GeneEnvironmental FactorEnvironmental Risk FactorEtiologyEuropeanExhibitsExposure toFITCFailureFellowshipFluorescein-5-isothiocyanateFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFunctional RNAFunctional disorderFutureG18G18 GeneGWA studyGWASGene ExpressionGene TargetingGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic DiseasesGenetic RiskGenetic TranscriptionGenetic studyGenomeGenomic medicineGenomicsGoalsHealthHi-CHumanHumulin RInsulinInsulin CellInsulin ResistanceInsulin Secreting CellIntracellular Communication and SignalingIslands of LangerhansIslet CellIslets of LangerhansKetosis-Resistant Diabetes MellitusKnowledgeLinkLipocortin V GeneLipocortin-VMapsMaturity-Onset Diabetes MellitusMeasuresMediatingMentorsMeta-AnalysisMetabolicMobility Shift AssayModern ManMolecularMolecular InteractionNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoncoding RNANoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNontranslated RNANovolin RNucleusObesityPAP-IPP4 GenePancreasPancreaticPancreatic IsletsPars endocrina pancreatisPathway interactionsPatientsPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPhasePhenotypePhysiciansPhysiologyPhysiopathologyPlacental Anticoagulant Protein IPlacental Protein 4PositionPositioning AttributeProcessProteinsPublishingQTLQuantitative Trait LociRNA ExpressionRNA SeqRNA sequencingRNAseqRegular InsulinRegulatory ElementReporterResearchRiskRisk-associated variantRoleSOCS GeneScientistSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSlow-Onset Diabetes MellitusStable Diabetes MellitusStaining methodStainsStressSubcellular ProcessSuppressor of Cytokine SignalingSuppressor of Cytokine Signaling GeneT2 DMT2DT2DMTechniquesTestingThapsigarginThe Jackson LaboratoryThromboplastin InhibitorTimeTissuesTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTunicamycinType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUntranslated RNAVAC-AlphaVariantVariationVascular Anticoagulant-AlphaWorkadiposityadult onset diabetesallelic variantannexin A5assay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological adaptation to stressbiological signal transductionblood glucose regulationbusiness-friendly environmentcareercausationcell resiliencecell resiliencycell stresscell typecellular resiliencecellular resiliencycollaborative atmospherecollaborative environmentcorpulencedata interpretationdisease causationdoctoral studentendoplasmic reticulum stressenvironmental riskenvironmental stressesenvironmental stressorepigenome editingepigenomic editingexperiencefunctional genomicsgel shift assaygenetic conditiongenetic disordergenetic variantgenome editinggenome medicinegenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic editinggenomic variantglucose controlglucose homeostasisglucose regulationin vivoinnovateinnovationinnovativeinsulin resistantinsulin secretioninsulin toleranceinteractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentisletketosis resistant diabetesmaturity onset diabetesnecrocytosisnoncodingpathophysiologypathwaypeer-group atmospherepeer-group environmentphysiologic stressesphysiologic stressorphysiological stressesprecision genomic medicineprogramspromoterpromotorreaction; crisisresilient to stressresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsensorsingle nucleotide variantskillssocial rolestress resiliencestress resiliencystress responsestress; reactionthree dimensionaltranscription factortranscriptome sequencingtranscriptomic sequencingtype 2 DMtype II DMtype two diabeteswhole genome association analysiswhole genome association studyβ-cellβ-cellsβCell
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PROJECT SUMMARY
Type 2 Diabetes (T2D) is a complex disease caused by both genetic and environmental factors. Genome-wide
association studies (GWAS) have identified 403 association signals at 243 loci (T2D variants) that increase T2D
genetic risk. Functional (epi)genomic analyses strongly suggest that non-coding T2D variants alter transcriptional…
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