grant
Dissecting the causal impact of prenatal HIV exposure and the postnatal environment on development in Malawian Infants
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-11 years old2nd trimester5 year old5 years of ageAIDS VirusAccountingAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAfrica South of the SaharaAgeAreaBioinformaticsBiologicalBiostatistical MethodsBirthBlood SampleBlood specimenCausalityChildChild DevelopmentChild HealthChild YouthChildhoodChildren (0-21)ClinicCohort StudiesCommunicable DiseasesComplexConcurrent StudiesCord BloodDataData SetData SourcesDevelopmentDevelopment PlansEnrollmentEnvironmentEnvironmental FactorEnvironmental Risk FactorEpidemiologistEquationEtiologyEvaluationExposure toFacultyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesGeneralized GrowthGestationGoalsGrowthHIVHIV InfectionsHIV-exposed uninfected infantHTLV-III InfectionsHTLV-III-LAV InfectionsHealthHome environmentHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIQ DeficitImmuneImmune MarkersImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic MarkersImmunologicalImmunologicallyImmunologicsImmunologyImpairmentInfantInfant DevelopmentInfant HealthInfant and Child DevelopmentInfectionInfectious Disease EpidemiologyInfectious DiseasesInfectious Diseases / LaboratoryInfectious Diseases ResearchInfectious DisorderInfectious EpidemiologyInflammationInflammatoryInterdisciplinary ResearchInterdisciplinary StudyInterventionIntervention StrategiesInvestigatorsLAV-HTLV-IIILanguage DevelopmentLeadershipLifeLymphadenopathy-Associated VirusMachine LearningMalawiMarylandMaternal and Child HealthMeasuresMental HealthMental HygieneMentorsMethodological StudiesMethodologyMethodsMidtrimesterModelingMother-Child RelationsMother-Child RelationshipMothersMotorMultidisciplinary CollaborationMultidisciplinary ResearchNatureNeonatalNeural DevelopmentNeurocognitiveNeurocognitive DeficitNyasalandOutcomeParturitionPregnancyPrincipal InvestigatorProductivityPsychological HealthPublic HealthResearchResearch MethodologyResearch MethodsResearch PersonnelResearchersRiskSecond Pregnancy TrimesterSecond TrimesterSeverity of illnessSocial BehaviorSocio-economic statusSocioeconomic StatusSub-Saharan AfricaSubsaharan AfricaT-CellsT-LymphocyteTechniquesTestingTissue GrowthTrainingTransmissionUmbilical Cord BloodUniversitiesVirus-HIVacquiring language skillsactive followupage 5 yearsagesarmbiologiccareercareer developmentcausal diagramcausal modelcausationcohortcommunicable disease transmissioncomplex datadata diversitydata integrationdesigndesigningdevelopmentaldimension reductiondimensionality reductiondisease causationdisease severitydisease transmissiondiverse dataearly childhoodeffective interventionefficacious interventionenrollenvironmental riskexamination questionsexecutive controlexecutive functionexposed in uterofetal cord bloodfetal exposurefive year oldfive years of ageflow cytophotometryfollow upfollow-upfollowed upfollowupglobal healthimmune-based biomarkersimmunological biomarkersimmunological markersimmunological statusimprovedin utero exposureinfectious disease transmissioninnovateinnovationinnovativeintelligence quotient deficitinterdisciplinary approachintervention designintra-uterine environmental exposureintrauterine environmental exposurekidslanguage acquisitionlanguage learninglarge data setslarge datasetsmachine based learningmaternal wellbeingmedical collegemedical schoolsmother child interactionmultidisciplinarymultidisciplinary approachneonatal immunityneurocognitive declineneurocognitive impairmentneurodevelopmentnovelontogenypediatricpostnatalprenatalprenatal exposureprenatally exposedpsychosocialreduce data dimensionreduce dimensionalityresearch and methodsschool of medicineskillssocio-economic positionsociobehaviorsociobehavioralsocioeconomic positiontherapy designthymus derived lymphocytetransmission processtreatment designunbornunsupervised clusteringyoungster
Description preview
PROJECT SUMMARY/ABSTRACT
Infant health and neurodevelopment in early life may be impaired by a wide range of prenatal and postnatal
factors including maternal infection and inflammation, and the socio-behavioral postnatal environment.
Identifying the independent impact of these exposures is critical for defining key interventions to improve infant…
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