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Dissecting Nrf2-dependent HIF1a activation mechanism in arsenic-induced cancer stem-like cells
Organization STATE UNIVERSITY NEW YORK STONY BROOKLocation STONY BROOK, UNITED STATESPosted 15 Sept 2021Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY2025AddressAffectArsenicAssayBasal Transcription FactorBasal transcription factor genesBioassayBiochemicalBiological AssayBladderBladder Urinary SystemC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer Causing AgentsCancersCarcinogensCas nuclease technologyCell BodyCell Communication and SignalingCell SignalingCellsChIP SequencingChIP-seqChIPseqCharacteristicsCitric Acid CycleClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyConsumptionCountryD-GlucoseDataDepositDepositionDextroseEarthEnvironmental CarcinogensEnvironmental ExposureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsExhibitsExposure toFoodFruitGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGlucoseGlycolysisGrainHIF 1 alphaHIF-1alphaHIF1-AlphaHIF1AHIF1A geneHIF1αHematologic Body SystemHematologic Organ SystemHematopoietic Body SystemHematopoietic SystemHistone H3HumanHydrogen OxideIn VitroIndustrializationIntermediary MetabolismIntracellular Communication and SignalingIrrigationJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK21B1/2Job LocationJob PlaceJob SettingJob SiteKidneyKidney Urinary SystemKrebs CycleL-LysineLinkLiverLungLung Respiratory SystemLysineMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMOP1MaintenanceMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMetabolicMetabolic ProcessesMetabolismMetalsMethylationMineralsMitochondriaMitogen-Activated Protein Kinase 8Modern ManOncogensOrganOxidative PhosphorylationOxidative Phosphorylation PathwayPRKM8Pathway interactionsPatternPersonsPlanet EarthPlayProteomicsPublic HealthPulmonary CancerPulmonary malignant NeoplasmRNA ExpressionRNA SeqRNA sequencingRNAseqResearchRiceRoleSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSignal TransductionSignal Transduction SystemsSignalingSkinSoilStem Cell likeStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaTCA cycleTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTricarboxylic Acid CycleUbiquitilationUbiquitinationUbiquitinoylationUnited StatesVegetablesWaterWork LocationWork PlaceWork-SiteWorkplaceWorksitearsenic carcinogenesisarsenic induced cancerarsenicsbiological signal transductionbronchial epitheliumc-jun N-Terminal Kinasecancer cell stemnesscancer progenitorcancer progenitor cellscancer stem cellcancer stem cell likecancer stem like cellcancer stemnesscancer typecarcinogenicitychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromatin remodelingdietary fruitdietary vegetableepigenetic biomarkerepigenetic markerepigeneticallyground watergroundwaterhepatic body systemhepatic organ systemhistone methylationin vivoinhibitorirrigation therapyjun-NH2-Terminal Kinaselung cancermalignancymalignant progenitormalignant stem cellmetabolism measurementmetabolomicsmetabonomicsmitochondrialmitochondrial metabolismneoplasm/canceroncogenic agentoncogenic progenitoroncogenic stem cellspathwayprogenitor capacityprogenitor cell likeprogenitor like cancer cellprogenitor-likerenalresponseself-renewself-renewalsocial rolestem cell characteristicsstem like cancer cellstem-likestemnessstemness in cancerstress-activated protein kinase 1targeted cancer therapytranscription factortranscriptome sequencingtranscriptomic sequencingtranscriptomicsubiquinationubiquitin conjugationurinary bladderwork setting
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Description preview
Long-term exposure to arsenic, esp. the inorganic trivalent arsenic (iAs), a human carcinogen that
occurs naturally in the earth's crust or work place due to industrial settings, has been linked to various
types of cancers, esp. lung cancer. It has been known for decades that multiple different mechanisms
might be involved in iAs-induced malignant…
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