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Dissecting Mechanisms of Striatal Acetylcholine Transmission in the Vertebrate Brain

Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Aug 2022Deadline 18 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025ACh ReceptorsAblationAcetylcholineAcetylcholine ReceptorsAffectAreaAxonBasal GangliaBasal NucleiBehaviorBody TissuesBrainBrain Nervous SystemBrain imagingCNS Nervous SystemCalciumCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCell Communication and SignalingCell SignalingCentral Nervous SystemCholinergic ReceptorsCholinoceptive SitesCholinoceptorsComplexConnector NeuronCorpus StriatumCorpus striatum structureDataDiseaseDisorderDistantDopamineElectrophysiologyElectrophysiology (science)ElementsEncephalonEnzyme GeneEnzymesEster HydrolaseExocytosisFunctional ImagingGenesGeneticGoalsHealthHydroxytyramineIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingLearningLocomotionMeasurementMeasuresMessenger RNAMiceMice MammalsModelingMolecularMorphologyMotivationMurineMusMyoneural JunctionNerveNerve CellsNerve UnitNervous System PhysiologyNeural CellNeuraxisNeurocyteNeurologic functionNeurological functionNeuromodulatorNeuromuscular JunctionNeuronsNeurophysiology / ElectrophysiologyNicotinic Acetylcholine ReceptorsNicotinic ReceptorsPhasePhosphatidesPhospholipidsPhysiologic ImagingProteinsReceptor ProteinRewardsSignal TransductionSignal Transduction SystemsSignalingSiteSliceStriate BodyStriatumStructureSynapsesSynapticSystemTestingTissue imagingTissuesTranscriptTransgenic OrganismsTransmissionVDCCVaricesVaricose VeinsVaricosityVesicleVoltage-Dependent Calcium ChannelsWorkbiological signal transductionbrain visualizationbrain volumecholinergicconditional knock-outconditional knockoutelectrophysiologicalesterasefluorescence imagingfluorescent imaginginsightmRNAmouse geneticsnanonervous system functionneural controlneural regulationneuromodulationneuromodulatoryneuronalneuroregulationp65 proteinphysiological imagingpresynapticreceptorscaffoldscaffoldingsecretory proteinsensorsocial cognitionspatial relationshipstriatalsuperresolution microscopysynapsesynaptic vesicle protein p65synaptotagmin 1synaptotagmin Itooltransgenictransmission processvesicle releasevesicular release

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Description preview

PROJECT SUMMARY
Acetylcholine critically controls complex neurological functions through its modulation of brain circuits. In
contrast to the well-studied mechanisms of acetylcholine signaling at the neuromuscular junction, its
transmission modes and mechanisms in the vertebrate central nervous system are not well understood. In the
striatum,…

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Dissecting Mechanisms of Striatal Acetylcholine Transmission in the Vertebrate Brain — HARVARD MEDICAL SCHOOL | UNITED S | Dev Procure