grant
Dissecting innate immune control of intestinal and systemic Yersinia infection
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 3 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026(TNF)-αAcuteAnimalsAntibiotic ResistanceBacteriaBacterial InfectionsBar CodesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD 120a AntigenCD120a AntigensCachectinCachectin ReceptorsCell BodyCell Communication and SignalingCell SignalingCellsChemotactic CytokinesCollaborationsComputational toolkitDataDevelopmentDiseaseDisorderEpithelial CellsEpitheliumFailureGI colonizationGastroenteritisGram-Negative BacteriaGranulomaGranulomatous LesionHomologous Chemotactic CytokinesHost DefenseIL-1IL1IL1RIL1R1IL1R1 geneIL1RAImmuneImmune EvasionImmune mediated therapyImmune responseImmune signalingImmune systemImmunesImmunochemical ImmunologicImmunocompetentImmunoglobulin Enhancer-Binding ProteinImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyInfectionInfection ControlInflammasomeInflammatoryInjectionsInnate Immune SystemInnate ImmunityIntercrinesInterleukin IInterleukin-1IntestinalIntestinesIntracellular Communication and SignalingLaboratoriesLesionLibrariesLiverLymphatic cellLymphocyteLymphocyte-Stimulating HormoneLymphocyticMacrophageMacrophage Cell FactorMacrophage-Derived TNFMarrow NeutrophilMarrow monocyteMediatingMiceMice MammalsMonocyte-Derived TNFMucosal Immune SystemMurineMusMyelogenousMyeloidMφNF-kBNF-kappa BNF-kappaBNFKBNative ImmunityNatural ImmunityNeutrophil ActivationNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNon-Specific ImmunityNonspecific ImmunityNuclear Factor kappa BNuclear Transcription Factor NF-kBOralOrganP pseudotuberculosisP. pseudotuberculosisPasteurella pestisPasteurella pseudotuberculosisPeyer's PatchesPhagocytosis InhibitionPhenocopyPlaguePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPredispositionProductionReporterReportingResistance to antibioticsResistant to antibioticsRouteSIS cytokinesSignal TransductionSignal Transduction SystemsSignalingSiteSmall IntestinesSourceSpleenSpleen Reticuloendothelial SystemStaining methodStainsStructureSusceptibilityT Helper FactorT3SSTIL4TLR2TLR2 geneTLR2 receptorTNFTNF ATNF AlphaTNF Receptor Family ProteinTNF Receptor SuperfamilyTNF Receptor p55TNF ReceptorsTNF geneTNF-sR55TNF-αTNF-α receptorTNFATNFARTNFRTNFR p60TNFR, 55-kDTNFR, 60-kDTNFR-ITNFR1TNFR55TNFR60TNFRSF1ATNFRSF1A ReceptorTNFRSF1A geneTNFalpha receptorTNFαTNFα receptorTestingTimeTissuesToll-Like Receptor 2Toll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4Transcription Factor NF-kBTumor Necrosis FactorTumor Necrosis Factor ReceptorTumor Necrosis Factor Receptor 1Tumor Necrosis Factor Receptor 55Tumor Necrosis Factor Receptor FamilyTumor Necrosis Factor Receptor SuperfamilyTumor Necrosis Factor-alphaType III Secretion SystemType III Secretion System PathwayVirulentWild Type MouseWorkY pestisY pseudotuberculosisY. pestisY. pseudotuberculosisYersiniaYersinia infectionsYersinia pestisYersinia pestis diseaseYersinia pseudotuberculosisYersinia pseudotuberculosis Infectionsantibiotic drug resistanceantibiotic resistantbacteria infectionbacteria pathogenbacterial diseasebacterial pathogenbarcodebiological signal transductionbowelchemoattractant cytokinechemokinecomputational pipelinescomputational toolboxcomputational toolscomputational toolsetcomputerized toolscytokinedeep sequencingdefined contributiondevelopmentalenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteropathogenenteropathogen infectionenteropathogenic infectionexperiencegastrointestinal tract colonizationgut colonizationhepatic body systemhepatic organ systemhost responseimmune competentimmune evasiveimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseinfected with enteropathogeninfection mouthinsightintestinal colonizationintestinal epitheliumintestinal infectionintestinal pathogenintestine infectionintestine pathogenkappa B Enhancer Binding Proteinlymph celllymphocyte activating factormesenteric lymph nodemesentery lymph nodemonocyteneutrophilnext generationnovelnuclear factor kappa betaoral infectionoral infectiouspathogenpathogenic bacteriapublic health relevancesmall bowelspatial and temporalspatial temporalspatiotemporalsynergismtumor necrosis factor alpha receptortumor necrosis factor receptor 1Atumor necrosis factor α receptortype 3 secretion systemwildtype mouse
Description preview
Project Summary
Infection by many pathogens leads to the formation of structures termed granulomas, organized clusters of
macrophages, neutrophils, and lymphocytes, that contain and control the infection, but can also serve as sites
for pathogen replication and dissemination. Infection by enteric Yersinia leads to the formation of pyogranulomas…
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