grant
Dissecting how gene regulatory redundancy ensures robustness of mammalian development
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3DAffectArchitectureAssayAttenuatedAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBioinformaticsBiologic ModelsBiological AssayBiological ModelsBiologyBirthBirth DefectsCUT&RUNCell BodyCell NucleusCellsChIP SequencingChIP-seqChIPseqChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseColorCombining SiteCommunicationComplexCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationConsultationsDNADNA mutationDataDeoxyribonucleic AcidDevelopmentDevelopmental BiologyDevelopmental GeneEducational process of instructingElementsEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEngineering / ArchitectureEnhancersEnsureExtra digitsExtremitiesFISH TechnicFISH TechniqueFISH analysisFISH assayFellowshipFluorescence Activated Cell Sorting FractionationFluorescence In Situ HybridizationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFluorescent in Situ HybridizationFunctional RNAGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic DiseasesGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomicsHyperdactylyImageIndividualInvestigatorsKI miceKnock-in MouseKnock-outKnockoutLabelLearningLimb BudLimb DevelopmentLimb structureLimbsLogicMammaliaMammalsMeasuresMentorshipMiceMice MammalsModel SystemModelingMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMorphogenesisMurineMusMutationNon-TrunkNoncoding RNANontranslated RNANucleusParturitionPathologyPatternPhenotypePolydactyliaPolydactylismPolydactylyRNA ExpressionReactive SiteRecombinant DNA TechnologyReporterReproducibilityResearchResearch PersonnelResearch ProposalsResearchersResolutionRoleSeveritiesSortingSpecificityTeachingTechniquesTestingTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenesTransgenic MiceTransgenic OrganismsUntranslated RNAUpstream Stimulatory FactorUpstream Transcription Factorattenuateattenuateschromatin conformation capturechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromosome capturechromosome conformation captureconformationconformationalconformational stateconformationallyconformationscongenital anomalyconsultationdevelopmentaldrivingexperimentexperimental researchexperimental studyexperimentsgene locusgene regulatory networkgenetic conditiongenetic disordergenetic locusgenetically engineeredgenome editinggenome mutationgenomic editinggenomic locationgenomic locushelix-loop-helix activator USFhuman embryogenesishuman embryonic developmentimagingimprovedin vivoknockin micemorphogenetic processmouse modelmurine modelnoncodingprogramspromoterpromotorrecruitresilienceresilientresolutionsskillssocial rolespatial and temporalspatial temporalspatiotemporalsuperresolution microscopythree dimensionaltranscription factortranscription factor MLTFtranscription factor USFtransgenetransgenic
Description preview
PROJECT SUMMMARY/ABSTRACT
Transcriptional enhancers are non-coding DNA elements that control the expression of their target genes with
spatiotemporal specificity. Transcription factors confer the specificity of enhancer function by recruiting core
transcriptional machinery to the enhancer’s target promoter during gene activation. Altered enhancer…
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