grant
Disrupting the Peri-necrotic Engine of Immunosuppression in Glioblastoma
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 17 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AccelerationApoplexyBiologicalBiologyBlood VesselsBone MarrowBone Marrow Reticuloendothelial SystemBone-Derived Transforming Growth FactorBrain DiseasesBrain DisordersBrain Vascular AccidentCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell Communication and SignalingCell Nucleus Active TransportCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCheckpoint inhibitorClinicalClinical TrialsDataDependenceDevelopmentDiseaseDisorderEncephalon DiseasesEventEvolutionFailureGene TranscriptionGeneralized GrowthGenetic TranscriptionGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrowthHypoxiaHypoxicImmuneImmune checkpoint inhibitorImmunesImmunityImmunocompetentImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfiltrationInflammatoryInnate Immune ResponseIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationMacrophageMalignantMalignant - descriptorMiceMice MammalsMilk Growth FactorModelingMolecularMurineMusMφNecrosisNecroticNeuroglial NeoplasmNeuroglial TumorNeurosphereNuclear TransportNucleocytoplasmic ShuttlingOxygen DeficiencyPathologicPatientsPatternPhasePhenotypePlatelet Transforming Growth FactorPre-Clinical ModelPreclinical ModelsPrimary Brain NeoplasmsPrimary Brain TumorsRNA ExpressionRadialRadiusRecurrenceRecurrentResearch ResourcesResourcesRoleSTAT3STAT3 geneSignal TransductionSignal Transduction SystemsSignalingSourceSterilityStrokeT8 CellsT8 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTherapeuticTherapeutic InterventionTimeTissue GrowthTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTumor PromotionTumor-associated macrophagesZYXZYX genebiologicbiological signal transductionbrain attackcancer microenvironmentcerebral vascular accidentcerebrovascular accidentcheck point inhibitioncheckpoint inhibitionchemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapyclinical relevanceclinically relevantdensitydevelopmentalglial-derived tumorglioblastoma multiformeimmune check point inhibitionimmune check point inhibitorimmune checkpoint inhibitionimmune competentimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmune suppressive macrophagesimmunosuppressive activityimmunosuppressive functionimmunosuppressive macrophagesimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentin vivoinhibitorinnovateinnovationinnovativeintervention therapymigrationmouse modelmurine modelneuroglia neoplasmneuroglia tumornucleocytoplasmic transportontogenypharmacologicpodoplaninradio-chemo-therapyradio-chemotherapyradiochemotherapyrecruitskillssocial rolespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalspongioblastoma multiformestandard of caresterilestrokedstrokestherapeutic agent developmenttherapeutic developmenttherapeutic targettherapeutically effectivetooltumor immune microenvironmenttumor microenvironmenttumor-immune system interactionsvascularzyxin
Description preview
Project Summary/Abstract
Glioblastoma, IDH-wildtype (GBM; WHO grade 4), the most malignant primary brain
tumor, has well-defined pre-necrotic, necrotic and recurrent growth phases. Transition to
the necrotic phase in primary and recurrent states involves a massive restructuring of
the tumor microenvironment (TME), in which there is a dramatic…
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