grant
Discovery/Signaling Core
Organization THOMAS JEFFERSON UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 20 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)Adrenergic ReceptorAdrenoceptorsAirway DiseaseArrestinsAsthmaBackBindingBiochemicalBiologyBronchial AsthmaBronchodilationCalcium Phospholipid-Dependent Protein KinaseCalcium-Activated Phospholipid-Dependent KinaseCell Communication and SignalingCell SignalingChemicalsComplexComputing MethodologiesCouplingCryo-electron MicroscopyCryoelectron MicroscopyCyclic AMPDataDockingDorsumDrugsElectron CryomicroscopyEpinephrine ReceptorsG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGPCRGTP-Binding ProteinsGTP-Regulatory ProteinsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHigh Throughput AssayInfrastructureIntracellular Communication and SignalingLeadLecithinase CMeasurementMedicationModelingMolecularMolecular Dynamics SimulationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsPb elementPharmaceutical PreparationsPharmacologyPhospholipase CPhospholipid-Sensitive Calcium-Dependent Protein KinasePrivate SectorProductionProtein Kinase CPublic SectorReagentReceptor ProteinRetinal S-AntigenSignal TransductionSignal Transduction SystemsSignalingStructureStructure-Activity Relationshipadenoreceptoradenosine 3'5' monophosphateantagonismantagonistbiological signal transductioncAMPchemical structure functioncomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcryo-EMcryoEMcryogenic electron microscopydesigndesigningdrug/agentflexibilityflexibleheavy metal Pbheavy metal leadhigh throughput screeningimprovedinnovateinnovationinnovativeinsightlipophosphodiesterase Imolecular dynamicsmolecular modelingnovelparticlephosphatidylcholine cholinephosphohydrolasepositive allosteric modulatorreceptorrecruitscreeningscreeningssmall moleculestructure function relationshipsynergismtranslational applicationsvirtual screeningvirtual screenings
Description preview
Core A - Abstract
The Discovery/Screening Core provides high throughput screening (HTS), cryo-electron microscopy, signaling
analysis, and virtual screening infrastructure to supply projects 1-4 with small molecules and mechanistic insight
to exploit novel molecular mechanisms to promote bronchodilation in constrictive airway diseases.…
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