grant
Discovery, Structural Studies and Biosynthesis of Biologically Active Natural Products and Natural Product-Like Inhibitors
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AchievementAchievement AttainmentAcidsAcyltransferaseAnabolismAnti Mycobacterial AgentsAnti-Bacterial AgentsAnti-Cancer AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntimycobacterial AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssayBioassayBioinformaticsBiologicalBiological AssayCancer DrugCell BodyCellsClinicalComplexDataData BasesDatabasesDedicationsDefectDrug PrecursorsEC 2.3EngineeringEnvironmentEnzymatic BiochemistryEnzyme GeneEnzymesEnzymologyFamilyFinding natural productsFoundationsFutureGene ClusterGeneralized GrowthGenetics-MutagenesisGenomicsGlycohydrolasesGlycosidasesGlycoside HydrolasesGoalsGrowthIn SituIn VitroLogicMDR organismMDR pathogenMRSAMacrolidesMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMetabolic GlycosylationMethicillin Resistant S. AureusMethodsMiscellaneous AntibioticMolecularMutagenesisMutagenesis Molecular BiologyNatural ProductsNatural product discoveryNeoplastic Disease Chemotherapeutic AgentsOrganismPKS enzymePathway interactionsPeptidesPhosphatidesPhospholipidsPreparationPro-DrugsProdrugsPseudo-natural productResistanceResolutionRibosomesSingle Crystal DiffractionSpecificityStructureSystemTherapeuticTherapeutic FungicidesTissue GrowthTransferaseTransferase GeneTumor-Specific Treatment AgentsUltraviolet SpectrophotometryValidationWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyanti-bacterialanti-cancer druganti-fungalanti-fungal agentsanti-fungal drugantibiotic resistant pathogenantimycobacterialbiologicbiosynthesiscellular targetingdata basedrug resistant pathogenentire genomefull genomefungusgenome sequencingglycosylationhost-associated microbeshost-associated microbial communitieshost-associated microbiotahost-associated microorganismsinfectious disease treatmentinhibitorinsightliving systemmarinemarine environmentmetabolism measurementmetabolomicsmetabonomicsmethicillin resistance Staphylococcus aureusmethicillin resistant Staphylococcus aureusmethicillin resistant strains of Staphylococcus aureusmicrobes genomemicrobial genomemicroorganismmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogennatural product inspirednatural product-likenaturally occurring productnovelontogenyopen sourcepathwaypolyketide synthasepolyketidespreparationsprogramsresilienceresilientresistantresolutionsscaffoldscaffoldingsecondary metabolitestructural biologyultraviolet spectrometryvalidationswhole genome
Description preview
The past year has yielded significant advances in natural product discovery, biosynthetic enzymology, and structural biology, with particular emphasis on Mass Spectrometry (MS) methods aimed at identifying understudied molecular scaffolds, novel RiPPs, bioactive polyketides, and the mechanisms of action of new antibacterials. One major achievement…
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