grant
Discovery of Novel Benzimadazole Resistance Mechanisms
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Jul 2020Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026AffectAlbendazoleAllelesAllelism TestAllelomorphsAncylostomatidaeAnthelminticsAntihelminthic AgentAntihelminthic DrugsBindingBody TissuesC elegansC. elegansC.elegansCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCaenorhabditis elegansCanadaCaprine SpeciesCas nuclease technologyCell BodyCellsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollectionCommunitiesComplementComplement ProteinsComplementation TestCryo-electron MicroscopyCryoelectron MicroscopyDALYDataDrug DesignDrug InteractionsDrug TargetingDrugsEarly DiagnosisEconomic BurdenElectron CryomicroscopyEvolutionExposure toFarmFutureGWA studyGWASGene ExpressionGenesGeneticGenetic Complementation TestGenomeGoalsGoatGoats MammalsHaemonchusHealthHelminthsHookwormsHumanIncrease lifespanInvestigatorsKnowledgeMapsMeasuresMedicationMedicineModelingModern ManMolecularMolecular InteractionMonitorMorbidityNematodaNematodesNerve CellsNerve UnitNeural CellNeurocyteNeuronsPakistanParasitesParasitic WormsParasitic nematodePersonsPharmaceutical PreparationsPhylogenetic AnalysisPhylogeneticsPoisoningPopulationPredispositionPrintingPublicationsResearchResearch PersonnelResearchersResistanceRuminantiaRuminantsSamplingScientific PublicationSoilSourceStructureSusceptibilitySystemTestingTherapeuticTimeTissuesTrans TestTranslatingTransmissionTubulinValidationVariantVariationVermifugesVeterinary Medicineantihelminthicbenzimidazolebenzimidazole resistancebenzimidazole resistantbeta Tubulinboost longevitycomplementationcomplementation analysiscomplementation approachcryo-EMcryoEMcryogenic electron microscopydefined contributiondisability-adjusted life yearsdrug/agentearly detectionelongating the lifespanenhance longevityexperimentexperimental researchexperimental studyexperimentsextend life spanextend lifespanextend longevityfoster longevitygenetic approachgenetic strategygenome editinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic editingimprove lifespanimprove longevityknock-downknockdownlifespan extensionmortalityneuronalnovelparasitic roundwormpathogenpoisonedprogramsprolong lifespanprolong longevitypromote lifespanpromote longevityprotein structureprotein structuresproteins structureresistance alleleresistance generesistance locusresistance mechanismresistance mutationresistantresistant alleleresistant generesistant mechanismresistant mutationresponseroundwormsuccesssupport longevitytransmission processvalidationswhole genome association analysiswhole genome association studyβ-Tubulin
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Project summary:
Parasitic nematodes impose a massive health and economic burden across much of the developing world,
infecting over one billion people. The morbidity and mortality inflicted by these devastating pathogens is partly
curtailed by mass drug administration (MDA) programs that depend on the continued efficacy of a limited
portfolio of…
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