grant
Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening
Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 2 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AccelerationAerobicAnabolismAnti-Bacterial AgentsAntibiotic TherapyAntibiotic TreatmentBile AcidsBiologicalC albicansC diffC difficileC. albicansC. diffC. difficileC.albicansCandida albicansCandidiasisCandidosisCell BodyCell ExtractsCellsClostridioides difficileClostridium difficileCommunicable DiseasesCommunitiesE coliE faecalisE faeciumE. coliE. faecalisE. faeciumEnterococcus faecalisEnterococcus faeciumEscherichia coliFinding natural productsFoundationsFutureGI microbiotaGastrointestinal microbiotaGene ClusterGeneralized GrowthGeneticGoalsGrowthHealthHigh Throughput AssayHumanInfectionInfectious DiseasesInfectious DisorderIntermediary MetabolismInvadedKnowledgeLibrariesMediatingMetabolic ProcessesMetabolismMethodsMicrobeModern ManMoniliasisNatural product discoveryOrganismPlayProductionRecurrenceRecurrentResearchRoleS aureusS faceiumS faecalisS faeciumS. aureusS. faceiumS. faecalisS. faeciumShort-Chain Fatty AcidsStaph aureusStaphylococcus aureusStreptococcus Group DStreptococcus faceiumStreptococcus faecalisStreptococcus faeciumStructureTherapeutic FungicidesTimeTissue GrowthVolatile Fatty AcidsWorkanti-bacterialanti-fungalanti-fungal agentsanti-fungal druganti-microbialanti-microbial peptideantimicrobialbacteria in the gutbacteria pathogenbacterial disease treatmentbacterial infectious disease treatmentbacterial pathogenbiologicbiosynthesisbuild resiliencebuild resiliencycolonization resistancedevelop resiliencedevelop resiliencyelectron diffractionenhance resilienceenhance resiliencyenteric microbial communityenteric microbiotafacilitate resiliencefecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationfungal pathogenfungi pathogengastrointestinal microbial floragut bacteriagut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahigh throughput screeninghuman florahuman microbial communitieshuman microbiotahuman microflorahuman-associated microbial communitieshuman-associated microbiotaimprove resilienceimprove resiliencyincrease resilienceincrease resiliencyinnovateinnovationinnovativeintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraliving systemmedical collegemedical schoolsmembermicrobe pathogenmicrobialmicrobial hostmicrobial pathogenmicrobial productsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathobiontpathogenpathogenic bacteriapathogenic funguspathogenic microbepreservationpreventpreventingprogramspromote resiliencepromote resiliencyresilience developmentresistance mechanismresistant mechanismschool of medicinescreeningscreeningssmall moleculesocial rolesuccessyeast infection
Description preview
Project Summary
The human gut microbiota plays a critical role in health, with one of its major roles being to protect the host from
microbial pathogens through a phenomenon known as colonization resistance. Effective colonization resistance
is associated with increased bacterial diversity within the gut microbiota, which likely enhances the…
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