grant
Discovery And Functional Genomics Of Environmental Response Genes
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAntioncogene Protein p53AssayAutoregulationB blood cellsB cellB cellsB-Cell ActivationB-CellsB-LymphocytesB-cellBindingBioassayBiogenesisBioinformaticsBiologicalBiological AssayBiological MarkersBirthBirth WeightBlood CellsBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SampleBlood granulocytic cellBlood leukocyteBlood monocyteBlood specimenBronchopulmonary DysplasiaCD14CD14 geneCD19CD19 geneCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD56CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCategoriesCell AgingCell BodyCell CycleCell Cycle ProgressionCell Division CycleCell LineCell SenescenceCellLineCellsCellular AgingCellular SenescenceCellular Tumor Antigen P53Chronologic Fetal MaturityCord BloodCytokine Signal TransductionCytokine SignalingCytokinesisCytoplasmic DivisionCytotoxic cellDNADNA DamageDNA InjuryDNA MethylationDNA SequenceDNA mutationData SetDeoxyribonucleic AcidDevelopmentDevelopmental GeneDiathesisDiseaseDisease susceptibilityDisorderEWASEnvironmentEnvironmental ExposureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessErythroblastsEventExposure toFetal AgeFutureGWA studyGWASGene ExpressionGenesGeneticGenetic ChangeGenetic DiversityGenetic PolymorphismGenetic VariationGenetic defectGenetic mutationGenomic approachGenomicsGenotypeGestational AgeGoalsGranular LeukocytesGranulocytic cellHealthHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoiesisHematopoietic CancerHematopoietic Cellular Control MechanismsHomeostasisHumanImmuneImmunesImpairmentIncidenceInfantInfectionInflammatory ResponseInnate ImmunityK lymphocyteLeukocytesLeukocytes Reticuloendothelial SystemLeukopoiesisLinear RegressionsLinkLinkage DisequilibriumLung DiseasesLymphatic cellLymphocyteLymphocyticLymphopoiesisMalignant Hematologic NeoplasmMarrow NeutrophilMarrow leukocyteMarrow monocyteMemory B CellMemory B-LymphocyteMethodsMethylationMicroarray AnalysisMicroarray-Based AnalysisMissionMitochondriaModern ManMolecularMolecular InteractionMutationNCAMNCAM1NCAM1 geneNK CellsNative ImmunityNatural ImmunityNatural Killer CellsNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeutrophil ActivationNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityNormoblastsNucleated ErythrocytesNucleated red blood cellNucleated red cellNucleotide SynthesisO elementO2 elementOncoprotein p53OrganOrigin of LifeOxygenOxygen Inhalation TherapyOxygen Therapy CareP53ParturitionPathogenesisPathway interactionsPeripheral Blood CellPhagocytosisPhenotypePhosphoprotein P53Phosphoprotein pp53Physiological HomeostasisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulation StudyPredispositionPremature InfantPreventative strategyPreventionPrevention strategyPreventive strategyProtein TP53Pulmonary DiseasesPulmonary DisorderPurines/Pyrimidines/Nucleotides/Nucleic Acids MetabolismRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqRegression AnalysesRegression AnalysisRegression DiagnosticsReplicative SenescenceReproducibilityResponse ElementsRibonucleic AcidRiskRisk AssessmentSignal PathwaySingle Base PolymorphismSingle Nucleotide PolymorphismSiteSmokerSmokingStatistical RegressionStrains Cell LinesSupplementationSurvival RateSusceptibilityT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTP53TP53 geneTRP53TechniquesTherapeuticTobacco smokingTobacco smoking behaviorTumor Protein p53Tumor Protein p53 GeneUmbilical Cord BloodVariantVariationWarburg TherapyWhite Blood CellsWhite CellWhole BloodWorkactivated B cellsadaptive immunityadulthoodbio-markersbiologicbiologic markerbiomarkerblood cell formationcDNA ArrayscDNA Microarraycell typechronic lung disease in infantschronic lung disease in neonatal infantschronic lung disease in neonateschronic lung disease in newbornschronic lung disease in prematuritychronic lung disease in preterm infantschronic lung disease of infancychronic lung disease of prematuritycultured cell linedesigndesigningdevelopmentaldifferential expressiondifferentially expresseddisease of the lungdisease riskdisorder of the lungdisorder riskearly biomarkersearly detection biomarkersearly detection markersepigenetic biomarkerepigenetic markerepigenetic variationepigeneticallyepigenomeepigenome profilingepigenome wide association analysisepigenome-wide association studiesepigenomic profilingfetal cord bloodfunctional genomicsgenome mutationgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic effortgenomic strategyglobal gene expressionglobal transcription profilegranulocytehuman tissueimprovedinfant chronic lung diseaseinfants born prematureinfants born prematurelyinfants with chronic lung diseaseinsightlater in lifelater lifeliability to diseaselung disorderlung functionlung maturationlymph celllymphocytopoiesismicroarray analysesmicroarray technologymitochondrialmonocyteneonatal careneonatal chronic lung diseaseneonatal periodneonateneurological diseaseneutrophilnewborn chronic lung diseasenon-smokernonsmokernucleated RBCsnucleotide metabolismoxygen administrationoxygen therapyp53 Antigenp53 Genesp53 Tumor Suppressorpathwayperipheral bloodpolymorphismpopulation-based studypopulation-level studypost-prematurity respiratory diseaseprecision medicineprecision-based medicineprematurepremature babypremature infant humanpremature neonatespremature newbornprematuritypreterm babypreterm infantpreterm infant humanpreterm infants with chronic lung diseasepreterm neonatepreterm newbornpromoterpromotorprospectiveprotein p53pulmonarypulmonary functionreplicative agingresponsesingle nucleotide variantstudies of populationsstudy of the populationsupplemental oxygenthymus derived lymphocytetobacco smoke exposuretraittranscriptional differencestranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsverification and validationwhite blood cellwhite blood corpusclewhole genome association analysiswhole genome association study
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Epigenomic profiling of isolated blood cell types reveals highly specific B cell smoking signatures and links to disease risk
Xuting Wang*, et al
Tobacco smoking alters DNA methylation profiles of immune cells which may underpin some of the pathogenesis of smoking-associated diseases. To link smoking-driven epigenetic effects in specific immune…
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