grant
Discovery and characterization of synthetic bioinformatic natural product anticancer agents
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Acid-Amino-Acid LigasesAlgorithmsAnimal ModelAnimal Models and Related StudiesAnti-Cancer AgentsAnti-cancer natural productsAnti-tumor Natural ProductsAntibiotic AgentsAntibiotic DrugsAntibioticsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsBacteriaBacterial GenomeBacterial natural productsBacterial-derived natural productBioinformaticsBiological FunctionBiological ProcessBiologyBreathingCancer DrugCancer cell lineCancersChemical StructureClinicalCloningCollectionDNADataDeoxyribonucleic AcidDevelopmentDrugsEnzyme GeneEnzymesFDA approvedFamilyFermentationFinding natural productsFunctional MetagenomicsFundingFutureGene ClusterGene TranscriptionGeneticGenetic TranscriptionGenomeGenomicsGoalsHumanIn VitroInstructionLaboratoriesLarge-Scale SequencingLeadLibrariesMalignant NeoplasmsMalignant TumorMedicationMetagenomicsMethodologyMethodsMicrobial Bioactive CompoundMicrobial Secondary MetaboliteMicrobial natural productMicrobial-Derived CompoundMiscellaneous AntibioticModelingModern ManNatural HistoryNatural ProductsNatural anti-cancer agentsNatural antineoplastic agentsNatural chemotherapeutic agentsNatural chemotherapeutic productsNatural product anti-neoplasticsNatural product discoveryNatural products from bacteriaNatureNeoplastic Disease Chemotherapeutic AgentsPb elementPeptide BiosynthesisPeptide SynthetasesPeptidesPharmaceutical PreparationsRNA ExpressionResistanceRespiratory AspirationRespiratory InspirationRewardsSamplingSoilSourceStructureStudy modelsTherapeuticTranscriptionTranslationsTumor-Specific Treatment Agentsacid aminoacid ligaseanti-cancer druganti-microbialanti-proliferative agentsantimicrobialantiproliferative agentsbioactive natural productschemical synthesiscytotoxicdesigndesigningdevelopmentaldrug discoverydrug/agentheavy metal Pbheavy metal leadin vivoinspirationlab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentmalignancymetagenomemicrobiomemodel of animalmutantnaturally occurring productneoplasm/cancernew anti-cancer agentnew anticancer agentnew anticancer drugnew antineoplasticnew cancer drugnext generationnovelnovel anti-cancer agentnovel anti-cancer drugnovel anticancer agentnovel anticancer drugnovel antineoplasticnovel cancer drugpeptide structurepeptide synthasepolyketidespressureprogramspublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databaseresistantscreeningscreeningssmall moleculesuccesstherapeutic agent developmenttherapeutic developmenttranslation
Description preview
Many of our most important therapeutics were inspired by bacterial small molecules (natural products, NPs).
Although microbial NPs display a wide range of bioactivities, they have offered their greatest utility as anticancer
agents and antibiotics. The incredible success of NPs as lead structures for therapeutic development is thought
to be due to…
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