grant
Discovery and Characterization of Novel Halogenases from the Human Microbiome and from Archaea
Organization UNIVERSITY OF TOLEDOLocation TOLEDO, UNITED STATESPosted 15 Sept 2021Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Agricultural ChemicalsAgrochemicalsArchaeaArchaebacteriaArchaeobacteriaArchaeonAromatic CompoundsArtificial GenesAssayBacteriaBindingBinding SitesBioassayBiochemicalBioinformaticsBiological AssayBiomedical ResearchBody TissuesBrainBrain Nervous SystemCell BodyCellsChemicalsChemistryCombining SiteCommunicationComplexConsensus SequenceConserved SequenceConsumptionCouplingCrystallizationCrystallographiesCrystallographyDNA Molecular BiologyDataDependenceDiffusionDropsDrugsE coliE. coliEncephalonEnd Point AssayEndpoint AssaysEnvironmentEnzyme GeneEnzyme KineticsEnzymesEscherichia coliEvolutionFamilyFamily memberFlavinsFluorescenceFluorescence SpectrophotometryFriendsFutureGenesGoalsHPLCHigh Performance Liquid ChromatographyHigh Pressure Liquid ChromatographyHigh Speed Liquid ChromatographyHigh Throughput AssayHumanHuman MicrobiomeImmunityIn VitroIndolesIntermediary MetabolismInvestigationIodination reactionKineticsL-TryptophanLevotryptophanMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedicationMetabolic ProcessesMetabolismMethodsMiningModern ManMolecular BiologyMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonitorORFsOpen Reading FramesPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhylogenetic AnalysisPhylogeneticsPiperazinesPreparationProceduresProcessProductionPropertyProtein Coding RegionProteinsReactionReactive SiteRoentgen RaysSequence AlignmentShapesSkinSoilStructureStudentsSubstrate InteractionSynthetic GenesTestingTimeTissuesTrainingTransition ElementsTryptophanVariantVariationWorkX ray diffractionX ray diffraction analysisX-RadiationX-Ray RadiationX-rayXrayXray diffractionanalytical methodaryl halidecareerchemical reaction ratechlorinationcommunity microbesconformationconformationalconformational stateconformationallyconformationsdata miningdataminingdepositorydiffuseddiffusesdiffusingdiffusionsdrug/agentflexibilityflexiblefungushalogenationhigh throughput screeninghuman-associated microbiomeimprovedin vitro Assayinsightinterestiodinationmembermetagenomemicrobe communitymicrobialmicrobial communitymicrobiomemicroorganism communitynovelpharmaceuticalpolymicrobial communitypreferencepreparationsreaction raterepositoryscaffoldscaffoldingsecondary metabolitesequencing alignmentstructural biologytooltransition metalundergradundergraduateundergraduate studentvapor
Description preview
PROJECT SUMMARY/ABSTRACT
Flavin-dependent halogenases (FDHs) are biosynthetic enzymes from bacteria and fungi that
catalyze regioselective C-X bond formation (X=Cl, Br) with various aromatic substrates. Their
regioselectivity and environmentally friendly reaction conditions make FDHs attractive candidates for green
synthesis of aryl halides to be…
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