grant
Discovery and application of new enzymes for amino acid and peptide modification
Organization PRINCETON UNIVERSITYLocation Princeton, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20262-ketoglutarate2-oxoglutarate3-D3-Dimensional3DAcid-Amino-Acid LigasesAddressAlkaloidsAmidesAmino AcidsBioinformaticsBiologicalCatalysisCell BodyCellsChemical StructureChemicalsDevelopmentDrug Synthesis and ChemistryEngineeringEnzymatic BiochemistryEnzyme GeneEnzymesEnzymologyFamilyGoalsGripsHealthHumanHydroxylasesMedicinal ChemistryMedicineMetabolic PathwayMethodsMixed Function OxidasesMixed Function OxygenasesModern ManModificationMonooxygenasesNatural ProductsNitrogenPathway interactionsPeptide SynthesisPeptide SynthetasesPeptidesPharmaceutic ChemistryPharmaceutical ChemistryPhasePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreparationProtein FamilyProtein ModificationProteinsPublic HealthReactionResearchRibosomesSiteStructureSynthesis ChemistrySynthetic ChemistryWorkacid aminoacid ligasealpha ketoglutarateaminoacidbiologiccellular targetingdevelopmentaldrug synthesisdrug-like chemicaldrug-like compounddrug-like moleculeenzyme pathwayfunctional groupgraspinterestmacromoleculemethod developmentnaturally occurring productnovelpathwaypeptide synthasepreparationsprogramssmall moleculethree dimensionaltoolα-ketoglutarateα-oxoglutarateαKG
Description preview
Project Summary/Abstract
The discovery of new bioactive compounds used for human medicine is driven by our ability to
rapidly and efficiently generate new chemical structures. One major challenge in this aim is the
development of synthetic strategies that allow us to prepare molecules with the three-dimensional
structural complexity that is…
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