grant
Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related Dementias
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD preventionAD related dementiaADRDAchievementAchievement AttainmentAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's diagnosisAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease diagnosisAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmmon HornAmyloidAmyloid SubstanceAndroid AppAndroid ApplicationAutopsyBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood VesselsBostonBrainBrain Nervous SystemBrain imagingCell Phone ApplicationCell phone AppCellular Phone AppCellular Phone ApplicationCerebrospinal FluidCessation of lifeClinicalClinical DataCognitiveCollectionCornu AmmonisDataData CollectionDeathDementiaDetectionDevicesDiagnosisDigital biomarkerDiseaseDisorderDrug TherapyEarly DiagnosisEncephalonFood and Drug AdministrationFrequenciesHealthHealth Care TechnologyHealth ResourcesHealth TechnologyHippocampusIndividualInternet of ThingsInterventionLife CycleLife Cycle StagesMRI ScansMT-bound tauMagnetic Resonance Imaging ScanMeasuresMediationMethodsModelingMonitorNegotiatingNegotiationNerve DegenerationNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeuron DegenerationNeuropsychologic TestsNeuropsychological TestsOnset of illnessPETPET ScanPET imagingPETSCANPETTPaperParticipantPatientsPharmacological TreatmentPharmacotherapyPhenotypePlasmaPlasma SerumPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredispositionPrimary Senile Degenerative DementiaRad.-PETRecommendationReportingResearchReticuloendothelial System, Serum, PlasmaRiskRisk BehaviorsRisky BehaviorSmart Phone AppSmart Phone ApplicationSmartphone AppStandardizationStructureSusceptibilitySymptomsThickThicknessTimeUSFDAUnited States Food and Drug AdministrationUniversitiesVascular DiseasesVascular DisorderWhite Matter Hyperintensityadjudicationadjudicative process and procedurealzheimer riskapp on a smartphoneapplication on a smartphoneat risk behaviorbio-markersbiologicbiologic markerbiomarkerblood vessel disorderblood-based biomarkerblood-based markerbrain MR imagingbrain MRIbrain healthbrain magnetic resonance imagingbrain visualizationbrain volumecell phone based appcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcerebral spinal fluidclinical centercognitive assessmentcognitive testingcohortcostdata resourcedementia riskdigitaldigital cognitive assessmentdigital cognitive testdigital datadigital healthdigital markerdigital modelsdigital phenotypingdigital technologydisease onsetdisease preventiondisease riskdisorder onsetdisorder preventiondisorder riskdrug interventiondrug treatmentearly detectionhippocampaliOS appiOS applicationiPhone AppiPhone Applicationinterestlife coursemachine learning based modelmachine learning modelmicrotubule bound taumicrotubule-bound taumobile phone appnecropsyneural degenerationneurodegenerationneurodegenerativeneurofilamentneurological degenerationneuronal degenerationneuropathologicneuropathologicalneuropathologynovelpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphase 3 trialphase III trialphone appphone applicationpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempre-clinical assessmentpreclinical assessmentprimary degenerative dementiarisk factor for dementiarisk for dementiasenile dementia of the Alzheimer typesensorsmartphone applicationsmartphone based appsmartphone based applicationspinal fluidsuccesstautau Proteinstau factorvascularvascular dysfunctionvascular risk factorvasculopathyτ Proteins
Description preview
PROJECT SUMMARY/ABSTRACT
Effective drug treatment for Alzheimer’s disease (AD) may well be on the horizon. While the amyloid-tau-
neurodegeneration (A/T/N) signature is recommended for the diagnosis of AD, it is not definitive for clinical
expression. Recent advance in digital technology provides a potentially low-cost and scalable approach to…
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