grant
Differentiation of uterine tissue-resident natural killer cells
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 2 Feb 2026Deadline 1 Feb 2030
NIHUS FederalResearch GrantFY2026Abnormal CellAddressAdoptive TransferAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBiologyBloodBlood Reticuloendothelial SystemBlood leukocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBone-Derived Transforming Growth FactorCell BodyCell Communication and SignalingCell CountCell FunctionCell LineageCell NumberCell PhysiologyCell ProcessCell SignalingCell TherapyCellsCells Placenta-TissueCellular FunctionCellular PhysiologyCellular ProcessCellular biologyComputer softwareCytotoxic cellDataDeciduaDecidua GraviditasDeveloping fetusDevelopmentDysfunctionEngineeringEnvironmentExhibitsFetal DevelopmentFetal Growth RestrictionFetal Growth RetardationFetal healthFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGeneral Transcription Factor GeneGeneral Transcription FactorsGenital DisordersGenomicsGestationGoalsGrowth AgentsGrowth FactorGrowth SubstancesHomeHumanIUGRImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapyIntracellular Communication and SignalingIntrauterine Growth RetardationInvestigationK lymphocyteKineticsKnowledgeLabelLeukocytesLeukocytes Reticuloendothelial SystemLifeLinkLitter SizeLymphatic cellLymphocyteLymphocyticLymphoid CellMapsMarrow leukocyteMaternal-Fetal ExchangeMediatingMiceMice MammalsMilk Growth FactorMiscarriageModern ManMolecularMurineMusNK CellsNatural Killer CellsNormal PlacentomaOutcomePatientsPeripheralPhenotypePhysiologicPhysiologicalPhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePlatelet Transforming Growth FactorPlayPopulationPrecursor NK-CellPrecursor Natural Killer CellPregnancyPregnancy ComplicationsPregnant UterusProductionProgenitor CellsProteins Growth FactorsReceptor ProteinRecurrenceRecurrentReporterReproduction ImmunologyReproductive HealthReproductive ImmunologyReproductive System DiseaseRoleSignal TransductionSignal Transduction SystemsSignalingSoftwareSourceSpontaneous abortionStromal CellsSubcellular ProcessTGF BTGF-betaTGF-beta ReceptorsTGF-βTGF-β ReceptorsTGFbetaTGFβTechniquesTestingTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor beta ReceptorsTransforming Growth Factor β ReceptorsTransforming Growth Factor-Beta Family GeneTransplacental ExposureTransplant RecipientsUterusWhite Blood CellsWhite CellWild Type Mouseadverse pregnancy outcomebiological signal transductioncell based interventioncell biologycell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapyclinical significanceclinically significantcomplications during pregnancyconfocal imagingdevelopmentaldevelopmental plasticityfetalflow cytophotometryhomesidiopathic infertilityimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimpaired fetal growthimprovedinnovateinnovationinnovativeinsightintra-uterine growth restrictionintra-uterine growth retardationintrauterine growth restrictionlymph cellmaternal-fetal interfacemouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathophysiologypregnancy-related complicationspregnantprenatal growth disorderpreventpreventingprogenitorreceptorreproductive diseasereproductive disorderreproductive outcomereproductive successreproductive system disordersocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cellstherapeutic agent developmenttherapeutic developmenttherapeutic targettranscription factortransplant patienttrophoblastunexplained infertilitywhite blood cellwhite blood corpusclewildtype mousewomb
Description preview
PROJECT SUMMARY
For a pregnancy to succeed, the immune environment at the maternal-fetal interface must be precisely regulated
to support fetal development. Uterine natural killer (uNK) cells–the most abundant lymphocyte at the maternal-
fetal interface–are thought to contribute to various physiological aspects of gestation crucial for fetal…
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