grant
Differentiation of human induced pluripotent stem cells as a tool to study the effects of type 2 diabetes loci.
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldASM1Abnormal KaryotypeAdultAdult HumanAdult-Onset Diabetes MellitusAffectAllelesAllelomorphsAlpha CellAssayB9 endocrine pancreasBWCRBeta CellBig BabyBindingBioassayBiologic ModelsBiological AssayBiological ModelsBirthweight HighBody TissuesCDKN1CCDKN1C geneCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCatalogsCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineCell SignalingCellLineCellsClone CellsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollecting CellCommunitiesCyclin-Dependent Kinase Inhibitor 1C GeneD-GlucoseD11S813EDNA mutationDataDevelopmentDextroseDiabetes MellitusDiazoxideDideoxy Chain Termination DNA SequencingDiseaseDisorderEndocrineEndocrine PancreasEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene Action RegulationGene CombinationsGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGenesGeneticGenetic ChangeGenetic defectGenetic mutationGlucagon CellGlucagon Secreting CellGlucoseGoalsH19H19 geneHaplotypesHeavy babyHereditaryHeterozygoteHigh birth weight babyHigh birth weight infantHigh birthweight babyHumanHumulin RHyperinsulinemiaHyperinsulinismHypermethylationHypoglycemiaINS geneIndigenous AmericanIndividualInheritedInsulinInsulin CellInsulin Secreting CellIntervening SequencesIntracellular Communication and SignalingIntronsIslands of LangerhansIslets of LangerhansKIP2KIP2 GeneKetosis-Resistant Diabetes MellitusLTRPC5Large babyLarge baby for gestational ageLarge birth weightLeadLinkage DisequilibriumLong Transient Receptor Potential Channel 5MGC4485MLSN1- and TRP-Related Gene 1MTR1MapsMaturity-Onset Diabetes MellitusMethylationModel SystemModelingModern ManMolecularMolecular InteractionMutationNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityP57-Kip2 GenePancreasPancreaticPancreatic IsletsPancreatic beta CellPancreatic β-CellParentsPars endocrina pancreatisPathogenesisPb elementPhenotypePrivatizationProceduresProtocolProtocols documentationRNA SeqRNA analysisRNA sequencingRNAseqRegular InsulinReportingResearch DesignRiskRisk-associated variantSanger SequencingSignal TransductionSignal Transduction SystemsSignalingSiteSlow-Onset Diabetes MellitusStable Diabetes MellitusStrains Cell LinesStructure of beta Cell of isletStudy TypeSystemT2 DMT2DT2DMTRPM5TRPM5 geneTherapeutic AgentsTherapeutic InterventionTimeTissuesTolbutamideTranscript Expression AnalysesTranscript Expression AnalysisTransient Receptor Potential Cation Channel, Subfamily M, Member 5TranslatingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVariantVariationadiposityadult onset diabetesadulthoodalpha-cellanalyze gene expressionbeta cell developmentbiological signal transductioncatalogcell typecellular differentiationchannel blockerscorpulencecultured cell linedevelopmentaldiabetesdiabetes riskdisease modeldisorder modelendocrine pancreas developmentepigeneticallyfetalflow cytophotometrygene expression analysisgene expression assaygene locusgenetic locusgenome mutationgenomic locationgenomic locusglucose metabolismglucose toleranceheavy metal Pbheavy metal leadheterozygosityhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshypoglycemichypoglycemic episodesiPSiPSCiPSCsimprintin uteroindigenous communityinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfancyinfantileinsulin regulationinsulin secretionintervention therapyisletislet developmentislet progenitorislet stem cellsketosis resistant diabetesmaturity onset diabetesmethylation patternmutation correctionp57pancreas beta cellpancreas progenitor cellpancreas stem cellspancreas β cellpancreatic b-cellpancreatic progenitorpancreatic progenitor cellparentpluripotencypluripotent statepreventpreventingprogenitorprogramsresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstudy designtherapeutic evaluationtherapeutic testingtooltranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstype 2 DMtype II DMtype two diabetesα-cellβ-cellβ-cellsβCell
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
A 35-day protocol to reprogram human induced pluripotent stem cells (hiPSCs) into glucose-responsive pancreatic beta-like cells has been developed. Differentiating cells are being used to study the effects of the type 2 diabetes (T2D)-associated variants on beta cell development and insulin secretory function by using CRISPR/Cas9 technology to…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click