grant

Developmental Therapeutics Research Program

Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Jul 1997Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AddressAntibodiesAntioncogene Protein p53Applications GrantsApplied ResearchApplied ScienceAreaArtsAwardBasic ResearchBasic ScienceBiologyCCSGCancer Center Support GrantCancer TreatmentCancersCellular Tumor Antigen P53Center for Cancer ResearchChemicalsChemistryClinicalClinical InvestigatorClinical ResearchClinical StudyClinical TrialsClinical Trials DesignClinical Trials NetworkCombination Drug TherapyCommunitiesConduct Clinical TrialsCytotoxic ChemotherapyCytotoxic TherapyDNA Damage RepairDNA RepairDNA mutationDecentralizationDevelopmentDevelopmental TherapeuticsDevelopmental Therapeutics ProgramDevelopmental TherapyDirect CostsDrug resistanceDrugsET-CTNEarly Therapeutic-Clinical Trials NetworkEngineeringEvaluationExperimental TherapiesFacultyFosteringFundingFutureGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGoalsGrantGrant ProposalsGrowthHead and NeckHead and Neck CancerHead and Neck CarcinomaHead and neck structureHybridsImmuneImmune mediated therapyImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyIncubatorsIndustryInstitutionInternationalInvestigational TherapiesInvestigational TreatmentsInvestigatorsInvestmentsJournalsLaboratoriesLeadLeadershipLungLung Respiratory SystemMagazineMalignant Head and Neck NeoplasmMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMedicationMedicineMelanomaMentorsMentorshipMissionModelingMolecularMolecular FingerprintingMolecular ProfilingMutationNCI Center for Cancer ResearchNational Clinical Trials NetworkOncoprotein p53P53PaperPatient SelectionPatientsPb elementPeer ReviewPharmaceutical PreparationsPharmacologyPhasePhosphoprotein P53Phosphoprotein pp53PolychemotherapyProcessProtein TP53Public HealthPublicationsPublishingPulmonary CancerPulmonary malignant NeoplasmResearchResearch PersonnelResearch ResourcesResearchersResistanceResource SharingResourcesRoleScienceScientific PublicationSiteSkinStructureTP53TP53 geneTRP53TechniquesTherapeuticTherapeutic ResearchTissue BanksTissue CollectionTissue GrowthTissue repositoryTrainingTranslatingTranslational ResearchTranslational ScienceTumor Protein p53Tumor Protein p53 GeneUnscheduled DNA SynthesisWorkYale Cancer Centeranti-cancer immunotherapyanti-cancer therapyanticancer immunotherapycancer immunotherapycancer therapycancer-directed therapyclinical candidatecombination chemotherapycombination pharmacotherapycommunity engagementdesigndesigningdevelopmentaldrug candidatedrug discoverydrug resistantdrug/agentearly clinical trialearly phase clinical trialearly phase trialengagement with communitiesexperimental therapeutic agentsexperimental therapeuticsgenome mutationhead/neck cancerheavy metal Pbheavy metal leadimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunotherapy for cancerimmunotherapy of cancerimprovedinnovateinnovationinnovativeinterdisciplinary collaborationlung cancermalignancymalignant head and neck tumormedical collegemedical schoolsmeetingmeetingsmembermethylation biomarkermethylation markermolecular profilemolecular signatureneoplasm/cancernew anti-cancer agentnew anticancer agentnew anticancer drugnew antineoplasticnew cancer drugnew drug targetnew drug treatmentsnew druggable targetnew drugsnew markernew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel anti-cancer agentnovel anti-cancer drugnovel anticancer agentnovel anticancer drugnovel antineoplasticnovel biomarkernovel cancer drugnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetontogenyp53 Antigenp53 Genesp53 Tumor Suppressorpatient populationpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacologicphase 1 trialphase I trialpre-clinicalpre-clinical studypreclinicalpreclinical studypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprogramsprotein p53rational designrecruitrefractory cancerresistance to Drugresistantresistant cancerresistant to Drugschool of medicinesocial rolestructural biologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttransdisciplinary collaborationtranslation researchtranslational investigationtranslational therapeuticstranslational therapytrial designtumor
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The highly collaborative, transdisciplinary Developmental Therapeutics (DT) Research Program is a critical translational innovation hub for Yale Cancer Center (YCC), bridging drug discovery and experimental therapeutics to translate preclinical discoveries to patients, while returning clinical advances to the bench for refinement. To achieve this…

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