grant
Developmental regulation of oscillatory expression
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAnteriorArabidopsisAutomobile DrivingBiologic OscillatorBiologic PacemakersBiological OscillatorsBiological PacemakersBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationComputer ModelsComputerized ModelsCoriumCutisCyclicityDermisDevelopmentDevelopmental ProcessEcdysisEndogenous OscillatorsEnsureFeedbackGene ExpressionGene FamilyGene ProteinsGene TranscriptionGenesGeneticGenetic TranscriptionHourM PhaseMammalian CellMesodermMessenger RNAMetabolic Protein DegradationMitosisMitosis StageMolecularMolecular Dynamics SimulationMoltingMorphogenesisMorphologyOutputPace StimulatorsPacemakersPatternPeriodicalsPeriodicityPhaseProbabilityProcessProliferatingProtein Gene ProductsProtein TurnoverProteinsRNA ExpressionRegulationRegulatory Protein DegradationReporterRhythmicitySegmentation ClockSegmentation Clock PathwaySkeletal MuscleSomitesTimeTissuesTranscriptTranscriptionTranscription InitiationTranscription RepressorTranscriptional ControlTranscriptional RegulationTranscriptional RepressorTranslation InitiationTranslationsVertebraeVertebralVertebrate AnimalsVertebratesVoluntary Musclecircadian clockcircadian pacemakercomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingdevelopmentaldrivinggenetic repressorin vivomRNAmRNA Expressionmolecular dynamicsmorphogenetic processnovelperiodicperiodicalposttranscriptionalpredictive modelingprogenitor cell maintenanceprogenitor maintenanceprotein degradationprotein expressionsomite formationsomitogenesisspine bone structurestem cell maintenancetranslationvertebratavertebrate embryos
Description preview
Biological oscillators, the rhythmic and regular increases and decreases of gene expression or protein activity,
drive many dynamic molecular and morphological processes. Probably the most familiar is the circadian clock,
but there are also ultradian clocks that operate on the order of minutes and/or hours. Examples of ultradian
clocks are those…
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