grant
Developmental Pathophysiology of Adverse Patterns of Substance Use in Adolescents with Anxiety
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202512-20 years oldAcuteAdolescenceAdolescentAdolescent YouthAeroseb-HCAffectiveAgeAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnxietyBehavioralBiological MarkersBrainBrain Nervous SystemCausalityCetacortCharacteristicsClinicCognitiveCort-DomeCortefCortenemaCortisolCortisprayCortrilDataData CollectionDermacortDetectionDevelopmentDiagnosisDifferences between sexesDiffers between sexesDiseaseDisorderDysfunctionEldecortEmotionalEncephalonEquipment and supply inventoriesEtiologyExhibitsExposure toFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderGoalsHeterogeneityHydrocortisoneHydrocortoneHytoneImpulsivityInformal Social ControlInterventionInventoryLinkLong-term prospective studiesLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingMonitorNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeural DevelopmentNeural PathwaysNeurobiologyNeurocyteNeuronsNuclear Magnetic Resonance ImagingNutracortOutcomePathway interactionsPatternPersonalized medical approachPhysiologicPhysiologicalPhysiologyPhysiopathologyPredicting RiskProcessProctocortRegulationReportingRestRiskRoleSalivarySamplingSelf RegulationSeveritiesSex DifferencesSexual differencesSocial Support SystemStressSubstance Use DisorderSupport SystemSurvey InstrumentSurveysSymptomsSystemTask PerformancesTestingTimeWorkYouthYouth 10-21Zeugmatographyacute stressadolescence (12-20)adolescent substance useagesalleviate symptomameliorating symptomamygdaloid nuclear complexanxiety symptomsanxious symptombehavior outcomebehavioral outcomebio-markersbiologic markerbiological adaptation to stressbiomarkerbiomarker identificationcausationclinical diagnosiscognitive controldecrease symptomdesigndesigningdevelopmentaldisease causationefficacious interventioneligible participantexternalizing behaviorfMRIfewer symptomsforecasting riskgraph theoryheart rate variabilityhigh riskhigh-risk adolescentsidentification of biomarkersidentification of new biomarkersimprovedindividualized approachinformation processingintervention designjuvenilejuvenile humanlong-term studylongitudinal courselongitudinal outcome studieslongitudinal, prospective studymarker identificationmedial temporal areamedial temporal lobemesial temporal areamesial temporal lobemultimodal modelingneuralneural imagingneural networkneuro-imagingneurobiologicalneurodevelopmentneuroimagingneurological imagingneuronalpathophysiologypathwaypersonalized approachprecision approachpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpredictive riskpredicts riskprogramsprospectivereaction; crisisrecruitreduce symptomsrelieves symptomsresponserisk predictionrisk predictionssecondary analysissex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesocial stresssocially stressedstress reactivitystress responsestress; reactionstressorsubstance usesubstance use among adolescentssubstance use among youthsubstance use and disordersubstance usingsubstance using adolescentssupport networksymptom alleviationsymptom reductionsymptom relieftailored approachtherapy designtreatment designyouth ageyouth substance use
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Description preview
The proposed 5-year R01 study will examine maturational pathways of biomarkers (neural connectivity and
stress physiology) to adverse patterns of substance use (APSU) in adolescents with anxiety symptoms to
improve precision-based, targeted intervention. Anxiety remains one of the most commonly diagnosed clinical
symptom domains in adolescence and…
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