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Development of Synaptic Inputs on Spinal Interneurons

Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 1 Jun 2004Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years oldAdultAdult HumanAffectAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnkleAran-Duchenne diseaseAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBrainBrain Nervous SystemCell BodyCellsCerebral PalsyChestChronicCompensationConnector NeuronCoxaCruveilhier diseaseCyclicityDataDerivationDerivation procedureDevelopmentDisinhibitionDissectionEncephalonExplosionExtensorFeedbackFlexorGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGoalsGrantHealthHeterogeneityHipHip region structureHumanIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIpsilateralKneeKnowledgeLabelLinkLocationLocomotionMediatingMedulla SpinalisMiceMice MammalsModelingModern ManMotorMotor CellMotor NeuronsMotor outputMovementMurineMusMuscleMuscle Cell ContractionMuscle ContractionMuscle TissueMuscular ContractionMyelin Basic Protein P2Myelin P2 ProteinNeonatalNerve CellsNerve UnitNeural CellNeurocyteNeuronsNewborn InfantNewbornsOrganizational OutputOrganizational ProductivityP2 ProteinPathway interactionsPatternPeriodicityPhasePlayPositionPositioning AttributePropertyProteinsRecurrenceRecurrentRegio tarsalisRenshaw CellReportingRhythmicityRoleShapesSourceSpeedSpinalSpinal CordSpinal Cord TraumaSpinal Muscular AtrophySpinal TraumaSpinal cord injuredSpinal cord injurySubgroupSynapsesSynapticSyndromeTestingThoraceThoracicThoraxTranscription Factor Proto-OncogeneTranscription factor genesTraumatic MyelopathyViralWorkadulthoodbody movementcombinatorialconnectomedevelopmentaldrivingfork head proteinforkhead proteinforkhead transcription factorsgenetic approachgenetic strategyjuvenile animalkinematic modelkinematicsmodel of animalmotoneuronmotor behaviormotor controlmotor deficitmotor diseasemotor disordermotor dysfunctionmuscle spindle reflexmuscularmyotatic reflexneonateneuronalnewborn childnewborn childrennovelpathwaypost-natal developmentpostnatalpostnatal developmentprogenitorrecruitsocial rolespatial and temporalspatial temporalspatiotemporalstretch reflexsynapsetranscription factortreadmillyoung animal

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PROJECT SUMMARY (30-lines)
Movement depends on patterned spinal cord motor output necessary for coordinated muscle actions. This

in turn, depends on spinal interneuron microcircuits that modulate motoneuron recruitment and firing. The

recent explosion of genetically-defined interneurons has revolutionized the study of spinal motor circuits…

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Development of Synaptic Inputs on Spinal Interneurons β€” EMORY UNIVERSITY | UNITED STATES | Jun 2004 | Dev Procure