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Development of Strategies for the Enantioselective Synthesis of Heterocycles and Acyclic Amines

Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Jul 2022Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAcademiaAccelerationAldehydesAlkynesAminesAreaBehaviorBiologyBiotechBiotechnologyCarbonCatalysisCharacteristicsChemicalsChemistryClinicalCollectionComplexCopperCouplingCu elementDevelopmentElementsGoalsGonyaulax ToxinHealthHumanImidazoleIminesIndustrializationIonsIsomerismLaboratoriesLiftingLigandsLiteratureMethodsMitilotoxinModern ManNatural ProductsNitrogenPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePiperazinesPositionPositioning AttributePreparationProcessPseudo-natural productPyrazinesPyridazinesPyrimidineReactionResearchRouteSamplingSaxitoninSaxitoxinScienceStructureSynthesis ChemistrySynthetic ChemistryTechnologyTransmissionWorkaminecatalystchiral moleculedesigndesigningdevelopmentalenantiomerimprovedisomermorpholinenatural product inspirednatural product-likenaturally occurring productnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnitronenovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypharmaceuticalpre-clinicalpreclinicalpreparationspyridinequinolinescaffoldscaffoldingscreeningscreeningssmall molecule therapeuticssuccessthree dimensionaltransmission process

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Project Summary/Abstract
This objective of this proposal is to develop new synthetic methods for the enantioselective synthesis of bioactive
molecules. Studies are centered on utilizing a new class of atropisomeric chiral biaryl ligand being developed in
our laboratory. Preliminary work has found that imidazole-based biaryl P,N-ligands excel at…

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