grant
Development of Sensitive and Specific Proteomic Biomarkers of Aging, Health, Frailty, and Morbidity in Human and Mouse Cohorts
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AgingBaltimoreBiological AgingBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBlood monocyteBody TissuesCaloric RestrictionCirculationClinicalCohort StudiesCollectionComplexConcurrent StudiesConduct Clinical TrialsCoupledData CollectionDevelopmentDiagnosticDiseaseDisorderEvaluationFutureGeneticGeroscienceGoalsHealthHumanInterventionIntervention StudiesIntervention TrialInterventional trialLongitudinal StudiesMarrow monocyteMeasuresMiceMice MammalsModelingModern ManMorbidityMorbidity - disease rateMurineMusObesityOutcomePathway interactionsPhenotypePhysiologicPhysiologicalPlasmaPlasma SerumProteinsProteomicsPublishingRapamuneRapamycinResearchReticuloendothelial System, Serum, PlasmaSamplingSenotherapeuticSerumSirolimusSurrogate End PointsSurrogate EndpointTestingTissuesTranslationsWorkadiposityage associatedage associated declineage clockage correlatedage dependentage dependent declineage linkedage relatedage related declineage specificaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging associatedaging biological markeraging biomarkeraging clocksaging markeraging populationaging preventionaging relatedanti aginganti geronicantiagingbio-markersbiologic markerbiological agebiological process of agebiomarkerbiomarker signatureblood-based biomarkerblood-based markercalorie restrictioncirculating biomarkerscirculating markersclinical phenotypeclock measuring biological ageclock measuring biological agingclock of biological agingcohortcorpulencedecline with agedevelopmentalfrailtygeroscientifichuman modelintervention researchinterventional researchinterventional studyinterventions researchlong-term studylongitudinal outcome studiesminimally invasivemodel of humanmonocytemortalitymouse modelmultimorbiditymultiomicsmultiple chronic conditionsmultiple omicsmurine modelnano particlenano-sized particlenanoparticlenanosized particlenew approachesnovelnovel approachesnovel strategiesnovel strategyobese individualsobese peopleobese personobese populationobese subjectsoutcome predictionpanomicspathwaypopulation agingprevent age relatedprevent agingprogramsproteomic signaturesenescencesenescentsexsuppress agingtooltranslationtreatment strategy
Description preview
To overcome the technical challenges associated with plasma proteomics, we developed workflows that utilize nanoparticle-based enrichment coupled with MS enabled comprehensive characterization of plasma and serum samples with high dynamic range. the secretome from senescent monocytes in culture in serum-supplemented culture conditions. Our…
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