grant
DEVELOPMENT OF SAS A SYNTHETIC AS01-LIKE ADJUVANT SYSTEM FOR INFLUENZA VACCINES
Organization INIMMUNE CORPORATIONLocation MISSOULA, UNITED STATESPosted 30 Sept 2023Deadline 29 Sept 2028
NIHUS FederalResearch GrantFY2023AdjuvantAgonistAntibodiesAntigensBacterial VaccinesBacterinChemistryCollaborationsContracting OpportunitiesContractorContractsCyclic GMPDevelopmentDrug KineticsExcretory functionExhibitsFerretsFormulationGenerationsGuanosine Cyclic MonophosphateH1N1H1N1 VirusH3N2H3N2 VirusHeadHomolog of Drosophila TOLLImmune responseImmunological responseInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza BInfluenza B VirusInfluenza VaccinesInfluenza Viruses Type BIntermediary MetabolismLeadMetabolic ProcessesMetabolismModelingOrthomyxoviruses Type BPb elementPharmacokineticsProteinsQS 21QS-21 AdjuvantQS21RecombinantsSafetySaponinsStimulon QS-21 AdjuvantSystemT-CellsT-LymphocyteTLR4TLR4 geneToll HomologueToxicologyVaccine AdjuvantVaccinesViral VaccinesabsorptioncGMPdevelopmentalexcretionfluflu vaccineflu virus vaccineheavy metal Pbheavy metal leadhost responseimmune system responseimmunogenimmunogenicityimmunoresponseinfluenza virus vaccinemanufacturenovelpre-clinicalpreclinicalscale upseasonal fluseasonal influenzathymus derived lymphocytetoll-like receptor 4vaccine against fluvaccine against influenza
Description preview
Inimmune is developing a second generation synthetic AS01-like adjuvant system (termed SAS), by partnering our novel fully synthetic TLR4 agonist INI-2002, with a semi-synthetic saponin for use in vaccines. Pre-clinically, SAS has demonstrated excellent antibody and T-cell immune responses when paired with a split flu antigen. This versatile…
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