grant
Development of Robust and Low-cost Vaccines Against Salmonella Paratyphi A
Organization GLAXOSMITHKLINE BIOLOGICALSLocation RIXENSART, BELGIUMPosted 15 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20255 year old5 years of ageAdvanced DevelopmentAffinityAfricaAnimal ModelAnimal Models and Related StudiesAntibodiesAntigensAsiaBiologicalCRM-197CRM197Cause of DeathCessation of lifeClassificationClinical EvaluationClinical ResearchClinical StudyClinical TestingClinical TrialsDataDeathDevelopmentDomestic RabbitDoseDrugsEffectivenessEnteralEntericFeverFormulationFundingFutureGlycoconjugatesGoalsGood Manufacturing ProcessGood manufacturing practiceGram-Negative BacteriaGrantHealthHigh PrevalenceHumanImmune responseIndividualInfectionInvestigational DrugsInvestigational New DrugsLMICLeadLicensingLifeMeasuresMedicationMembraneMiceMice MammalsModelingModern ManMurineMusOryctolagus cuniculusParatyphoid FeverPb elementPharmaceutical PreparationsPhasePhase I StudyProcessProductionPyrexiaRabbitsRabbits MammalsS entericaS enterica serovar Paratyphi AS enterica serovar TyphiS enterica serovar TyphimuriumS paratyphiS typhiS typhimuriumS typhosaS. entericaS. enterica TyphimuriumS. enterica serovar Paratyphi AS. enterica serovar TyphiS. enterica serovar TyphimuriumS. paratyphiS. typhiS. typhimuriumS. typhosaSafetySalmonellaSalmonella VaccinesSalmonella entericaSalmonella enterica TyphimuriumSalmonella enterica serovar Paratyphi ASalmonella enterica serovar TyphiSalmonella enterica serovar TyphimuriumSalmonella paratyphiSalmonella paratyphi ASalmonella typhiSalmonella typhimuriumSalmonella typhosaSalmonellosis VaccinesSamplingSeriesStructureSystematicsTechnologyTestingToxic effectToxicitiesToxicologyVaccine Against SalmonellaVaccinesVesicleWorkage 5 yearsbactericidalbactericidebiologicclinical testcostcross reacting material 197developmentaldiarrheal diseasediarrheal illnessdrug/agententeral infectionenteric infectionenteric pathogen infectionenteropathogen infectionenteropathogenic infectionexperimentexperimental researchexperimental studyexperimentsfebrilefebrisfive year oldfive years of agefood-born illnessfood-borne diseasefood-borne illnessfoodborn illnessfoodborne diseasefoodborne illnessgastrointestinalglobal healthgood laboratory practiceheavy metal Pbheavy metal leadhost responseimmune system responseimmunogenimmunogenicityimmunoresponseimprovedinfected with enteropathogenintestinal infectionintestine infectionlow and middle-income countriesmanufacturemanufacturing processmembrane structuremodel of animalphase 1 studypre-clinicalpre-clinical evaluationpre-clinical studypreclinicalpreclinical evaluationpreclinical studypreventpreventingresearch clinical testingscale upvaccine candidatevaccine safety
Description preview
Project Summary / Abstract –
Development of Robust and Low-cost Vaccines for Preventing S. Paratyphi A:
Salmonella enterica is a Gram-negative bacterium that is a leading cause of foodborne illnesses
globally. In fact, Salmonella deaths are the first cause of death within enteric and diarrheal diseases and the
second cause of death in under…
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