grant
Development of Patient-Tailored Adaptive Treatment Strategies for Acute Severe Ulcerative Colitis
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 14 Jul 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025(TNF)-α18 year old18 years of ageAccountingAchievementAchievement AttainmentAcuteAddressAdmissionAdmission activityAdrenal Cortex HormonesApplications GrantsApplied ResearchApplied ScienceAreaAwardBehavioralC-reactive proteinCachectinCalcineurin antagonistCalcineurin inhibitorCaringCessation of lifeCharacteristicsCiclosporinClinicalClinical Trials DesignCognitive DiscriminationColectomyCorticoidsCorticosteroidsCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCsACyclosporin ACyclosporineCyclosporine ADataData AnalysesData AnalysisData AnalyticsDeathDeath RateDeteriorationDevelopmentDiscriminationDiseaseDisorderDrug TherapyEarly identificationEnsureFecesFrequenciesFutureGeneral HospitalsGeneralized GrowthGoalsGrant ProposalsGranulomatous EnteritisGrowthHealthHeterogeneityHospital AdmissionHospitalizationIndividualInflammatory Bowel DiseasesInflammatory Bowel DisorderInstitutionInterventionIntravenousInvestigatorsJAK kinaseJanus kinaseKnowledgeLaboratoriesLifeLinkMAb cA2Machine LearningMacrophage-Derived TNFMalignantMalignant - descriptorMassachusettsMentorshipMethodsMichiganModelingMonocyte-Derived TNFMorbidityMorbidity - disease rateParticipantPathway interactionsPatient AdmissionPatient SelectionPatientsPharmacological TreatmentPharmacotherapyPhysiciansPositionPositioning AttributePrecision carePrediction of Response to TherapyPreparationProbabilityProteins, specific or class, C-reactiveRandomizedRefractoryRemicadeResearchResearch PersonnelResearch ProposalsResearchersRiskSandimmunSangCyaScientistSequential Multiple Assignment Randomized TrialSequential TreatmentSpecific qualifier valueSpecifiedSteroid CompoundSteroidsSymptomsTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTimeTissue GrowthTrainingTreatment EfficacyTreatment FailureTumor Necrosis FactorTumor Necrosis Factor-alphaUlcerated ColitisUlcerative ColitisUniversitiesWorkacceptability and feasibilityage 18 yearsanalytical methodbrief interventionbrief therapybrief treatmentcareercohortcomputer based predictionconferenceconventioncostdata interpretationdetermine efficacydevelopmentaldrug interventiondrug treatmenteffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationeighteen year oldeighteen years of ageeleocolitisevaluate efficacyevidence baseexamine efficacyhigh dimensional dataimprovedindividual patientindividual responseindividualized careindividualized patient careindividualized responseindividualized strategiesinflammatory disease of the intestineinflammatory disorder of the intestineinfliximabinhibitorintervention efficacyintestinal autoinflammationkinase inhibitormachine based learningmachine learning based methodmachine learning based modelmachine learning methodmachine learning methodologiesmachine learning modelmonoclonal antibody cA2mortality ratemortality ratiomultidimensional datamultidimensional datasetsneoralnew approachesnovel approachesnovel strategiesnovel strategyontogenypathwaypersonalization of treatmentpersonalized carepersonalized medicinepersonalized patient carepersonalized strategiespersonalized therapypersonalized treatmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspredict therapeutic responsepredict therapy responsepredictive modelingpreparationsprognosticprospectivepublic health relevancerandomisationrandomizationrandomly assignedregional enteritisresponse to therapyresponse to treatmentsandimmunestoolsummitsymposiasymposiumtherapeutic efficacytherapeutic responsetherapy efficacytherapy failuretherapy predictiontherapy responsetreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstreatment strategytrial design
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Modified Project Summary/Abstract Section
This K23 application proposes a focused training and research plan to support the applicant’s career growth into an independent physician-scientist. The proposed plan will ensure the applicant develops expertise in patient-tailored adaptive treatment strategies (ATS) that deliver personalized care to…
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