grant
Development Of New Chemotherapeutics For Tuberculosis
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025ATP phosphohydrolaseATPaseActive Follow-upAddressAdenosine TriphosphataseAdherenceAdverse ExperienceAdverse eventAlaska IndianAlaska NativeAlaskan AmericanAlaskan IndianAlaskan NativeAlaskan Native AmericanAnabolismAntibiotic TherapyAntibiotic TreatmentAntitubercular DrugsAreaAssayAutoregulationBacteriaBindingBioassayBiochemistryBiological AssayBiological ChemistryBiologyCell RespirationCell WallCellular RespirationChemicalsClinical EvaluationClinical TestingCollaborationsCollectionCountryCryo-electron MicroscopyCryoelectron MicroscopyDNA ResequencingDNA mutationDevelopmentDiseaseDisease OutbreaksDisorderDiversity LibraryDoseDrug CostsDrug DesignDrug PrecursorsDrugsEarly-Stage Clinical TrialsElectron CryomicroscopyElectronsEnsureEnzyme GeneEnzymesEquilibriumExclusionExcretory functionFrequenciesFutureGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGenesGenetic ChangeGenetic defectGenetic mutationGenus MycobacteriumGoalsGrowthGuidelinesHigh Throughput AssayHomeostasisHumanHuman MicrobiomeIn VitroIn vivo analysisIntermediary MetabolismKansasKineticsLabelLeadLibrariesLigandsM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMedical ResearchMedicationMercaptansMercapto CompoundsMetabolicMetabolic ProcessesMetabolismMicrosomesMissouriMitochondriaModern ManMolecular InteractionMonitorMutationMycobacteriumMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNatural ProductsNatural SourceNegative Beta ParticleNegatronsOrganismOutbreaksOutcomeOxazolidinonesOxidation-ReductionPK/PDPathogenesisPathway interactionsPb elementPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhase 1 Clinical TrialsPhase I Clinical TrialsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPositionPositioning AttributePro-DrugsProdrugsPropertyProteinsPublic HealthRNA SeqRNA sequencingRNAseqRecombinantsRecommendationRedoxRegimenReporterResearch InstituteResequencingResistanceRespirationRibosomesRoleSeriesSiteSolubilityStressSulfhydryl CompoundsSystemTB chemotherapyTB drugsTB infectionTB therapyTB treatmentTRSTestingTherapeuticThermodynamicThermodynamicsThiolsTissue GrowthTitrationsToxinTranscript Expression AnalysesTranscript Expression AnalysisTraumeel STreatment PeriodTreatment ProtocolsTreatment RegimenTreatment ScheduleTuberculosisUnited StatesWorkXenobioticsabsorptionactive followupaerobic metabolismaerobic respirationanalyze gene expressionanti-TB drugsanti-toxinanti-tuberculosis drugsbacterial disease treatmentbacterial infectious disease treatmentbalancebalance functionbiosynthesischemical librarychemical synthesischemotherapyclinical testcofactorcrosslinkcryo-EMcryoEMcryogenic electron microscopycytotoxicdevelopmentaldisseminated TBdisseminated tuberculosisdrug candidatedrug developmentdrug/agententire genomeexcretionfollow upfollow-upfollowed upfollowupfull genomefungusgene expression analysisgene expression assaygenome mutationglobal healthheavy metal Pbheavy metal leadhigh throughput screeninghuman-associated microbiomeimprovedin vivoin vivo evaluationin vivo testinginfection due to Mycobacterium tuberculosisinhibitorinterestlead optimizationlead seriesliving systemmembermetabolism measurementmetabolomicsmetabonomicsmicrobialmitochondrialmtbmycobacterialnano-molarnanomolarnaturally occurring productnew chemical entitynovelontogenyoxidationoxidation reduction reactionoxidative metabolismpathogenpathwaypharmaceuticalpharmacokinetics and pharmacodynamicspharmacophorephase I protocolpre-clinicalpreclinicalprotein complexresearch clinical testingresistance frequencyresistantrespiratoryrespiratory mechanismresponsesafety studysafety testingscaffoldscaffoldingscreeningscreeningssecondary metabolitesmall molecule librariessocial rolesulfhydryl grouptranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistreatment daystreatment durationtuberculosis chemotherapytuberculosis drugstuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyuptakewhole genome
Description preview
Tuberculosis has recently re-emerged as a public health concern in the United States. Current treatments require a minimum of 4 months of treatment which becomes cumulatively expensive not only due to the cost of the drugs but also due to the requirement of therapeutic monitoring to ensure adherence during the extensive treatment. To address the…
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