grant
Development of multinuclear MRI for image guided therapy of glioma patients
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202519q1H- Nuclear Magnetic Resonance Spectroscopic ImagingAbscissionAccelerationAddressAdjuvant TherapyAminoacetic AcidAnatomic SitesAnatomic structuresAnatomyAssayBioassayBiological AssayBiopsyBrainBrain CancerBrain Nervous SystemCNS TumorCNS neoplasmCancer TreatmentCancersCentral Nervous System NeoplasmsCentral Nervous System TumorsChromosome 19 Distal ArmChromosome 19 Long ArmClassificationClinicalClinical TrialsComputer softwareConsensusCystathionineDNA mutationData AnalysesData AnalysisDetectionDevelopmentDiagnosisDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideDrug TherapyEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExcisionExtirpationFrameless StereotaxyGene ExpressionGenetic ChangeGenetic defectGenetic mutationGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGlnGlutamatesGlutamineGlycineGoalsGrantH+ elementHybridsHydrogen IonsImageImage-Guided SurgeryImaging DeviceImaging InstrumentImaging ToolImmune mediated therapyImmune systemImmunologically Directed TherapyImmunotherapyIndividualIntermediary MetabolismIsocitrate DehydrogenaseL-GlutamateL-GlutamineLabelLifeLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMRSIMagnetic Resonance ImagingMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMapsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethodsMissionModalityMolecularMonitorMultiparametric AnalysisMutationNMR ImagingNMR TomographyNadideNeuroglial NeoplasmNeuroglial TumorNeuronavigationNeurosurgeonNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNuclearNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOutcomePETPET ScanPET imagingPETSCANPETTPatientsPerformancePharmacological TreatmentPharmacotherapyPhosphorousPhosphorusPhosphorylationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Brain NeoplasmsPrimary Brain TumorsProgression-Free SurvivalsProtein PhosphorylationProton Magnetic Resonance Spectroscopic ImagingProtonsPublic HealthQ LevoglutamideQ. LevoglutamideQOLQuality of lifeRad.-PETRadiationRelapseRemovalReportingResearchResistanceResolutionRoleSKILSKIL geneSNOSampling BiasesScanningSensitivity and SpecificitySoftwareSpecificitySurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurvival RateSystematicsTechniquesTestingTimeTracerWorkWorld Health OrganizationZeugmatographyadjuvant treatmentanatomic imaginganatomical imaginganti-cancer therapybrain tumor resectioncancer imagingcancer progressioncancer therapycancer-directed therapychemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapyclinical translationclinically translatablecost effectivecustomized therapycustomized treatmentdata interpretationdata qualitydeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydevelopmentaldrug interventiondrug treatmentepigeneticallyfluorescence-guided surgerygenome mutationglial-derived tumorglutamatergicimage guided therapyimage-based methodimagingimaging in vivoimaging methodimaging modalityimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedimproved outcomein vivoin vivo imagingindividual patientindividualized cancer careindividualized medicineindividualized oncologyindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativeintra-operative imagingintraoperative imaginglong-term studylongitudinal outcome studiesmagnetic resonance spectroscopic imagingmalignancymetabolic imagingmetabolism measurementmetabolomicsmetabonomicsmolecular biomarkermolecular imagingmolecular markermolecular pathologymolecule imagingmultiparametric imagingmutantneoplasm progressionneoplasm/cancerneoplastic progressionneuro-oncologyneuro-surgeonneuroglia neoplasmneuroglia tumorneurooncologynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetoncologic imagingoncology imagingoptimal therapiesoptimal treatmentspatient specific therapiespatient specific treatmentpatient stratificationpersonalized oncologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprecision cancer careprecision cancer medicineprecision oncologypreventpreventingradio-chemo-therapyradio-chemotherapyradiochemotherapyreconstructionresectionresistantresolutionsresponseresponse to therapyresponse to treatmentsocial rolestratified patientsurgerysurgical imagingtailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetreatment planningtreatment responsetreatment responsivenesstumortumor imagingtumor of the central nervous systemtumor progressiontumors in the central nervous systemunique treatmentward
Description preview
7. Project Summary/Abstract
Gliomas have a low survival rate of 36% at five-years, half the average survival rate across all cancers
according to the last SEER and CBTRUS reports. Malignant brain tumors cause on average 20 years of
potential life lost (YPLL), exceeding most cancers. Survival and YPLL have not improved for gliomas as in
other…
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