grant
Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAccelerationAccuracy of DiagnosisAdjuvant ChemotherapyAdjuvant Drug TherapyAdoptionAntibodiesBiologicalBrain MappingBreastBreast CancerBreast NeoplasmsBreast TissueBreast TumorsCancer CauseCancer EtiologyCessation of lifeCharacteristicsClinicalClinical EvaluationClinical TestingComputersConsumptionConvNetDWI (diffusion weighted imaging)DWI-MRIDataDeathDevelopmentDictionaryDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingERBB2ERBB2 geneEarly DiagnosisEligibilityEligibility DeterminationEndocrine TherapyExhibitsFemaleFingerprintGeneticGoalsHER -2HER-2HER2HER2 GenesHER2/neuHeterogeneityHormonal TherapyImageIn complete remissionInduction TherapyLesionMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMagnetic ResonanceMagnetic Resonance ImagingMalignant Breast NeoplasmMammary CancerMammary Gland ParenchymaMammary Gland TissueMammary NeoplasmsMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMonitorMorphologyMultiparametric AnalysisNEOADJNEU OncogeneNEU proteinNMR ImagingNMR TomographyNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentNuclear Magnetic Resonance ImagingOncogene ErbB2Operative ProceduresOperative Surgical ProceduresPathologicPatient CarePatient Care DeliveryPatientsPhenotypePhysiciansPhysicsPhysiologicPhysiologicalPrediction of Response to TherapyPreparationProne PositionProtocol ScreeningRelaxationReproducibilityResolutionSamplingScanningStandardizationSurgicalSurgical InterventionsSurgical ProcedureTKR1TNBCTechniquesTherapeuticTimeTreatment outcomeVariantVariationVisualizationWomanZeugmatographyalgorithm trainingbiologicbreast exambreast examinationbreast examinationsbreast imagingbreast lesionbreast surgeryc-erbB-2c-erbB-2 Genesc-erbB-2 Proto-Oncogenescancer diagnosiscare for patientscare of patientscaring for patientschemotherapyclinical testclinical translationclinically translatablecloud basedcohortcomplete responseconvolutional networkconvolutional neural netsconvolutional neural networkcostcustomized therapycustomized treatmentdMRIdeep learningdeep learning methoddeep learning strategydevelopmentaldiagnostic accuracydiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsearly biomarkersearly detectionearly detection biomarkersearly detection markerserbB-2 Genesexperimentexperimental researchexperimental studyexperimentshealthy volunteerherstatinhormone therapyimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinduction therapiesineffective therapiesineffective treatmentinventionmagnetic fieldmagnetic resonance imaging biomarkermagnetic resonance imaging markermalignant breast tumormammary imagingmammary tumorneu Genesnovelpartial responsepatient responsepatient specific responsepatient specific therapiespatient specific treatmentpredict therapeutic responsepredict therapy responsepreparationsquantitative imagingreconstructionresearch clinical testingresearch studyresolutionsresponseresponse to therapyresponse to treatmentresponsive patientside effectsurgerytailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic outcometherapeutic responsetherapy outcometherapy predictiontherapy responsethree dimensionaltissue maptissue mappingtool developmenttreatment planningtreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstrendtriple-negative breast cancertriple-negative invasive breast carcinomatumorunique treatmentvolunteer♀
Description preview
Abstract
In women, breast cancer is the most commonly diagnosed cancer and leading cause of cancer related deaths
worldwide, with approximately 2.3 million new cases and 685,000 deaths in 2020. Neoadjuvant chemotherapy
(NAC) is commonly applied to reduce the tumor size before surgery for breast neoplasms. Unfortunately, due
to the genetic and…
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