grant
Development of an immunocompetent colon chip to model Crohn's Disease
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 6 Mar 2026Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202621+ years old3-D3-Dimensional3DAddressAdherent CultureAdultAdult HumanAffectAllogenicAmericanAnimalsAnionic Neutrophil-Activating PeptideAntigen PresentationAntigensArchitectureAutologousBacteriaBiochemicalBiomedical EngineeringBiophysicsBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCausalityCell BodyCell ComponentsCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell StructureCell surfaceCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StructuresCelluloseChemicalsChemotactic CytokinesChemotactic Factor, Neutrophil, Monocyte-DerivedChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesCollectionColonColonic DiseasesComplexCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCultured Neoplastic CellsCultured Tumor CellsDevelopmentDiagnosisDietDigestive DiseasesDigestive System DiseasesDigestive System DisordersDiseaseDisease remissionDisorderEngineering / ArchitectureEpithelial CellsEpitheliumEtiologyEventExperimental ModelsFecesGCP-IL-8GI Stem cellGI tract disorderGastroenterologyGeneticGoalsGoblet CellsGranulocyte Chemotactic Peptide-Interleukin-8Granulomatous EnteritisHealthHomologous Chemotactic CytokinesHousingHumanHydrogelsImageImmuneImmune ToleranceImmune reactionImmune systemImmunesImmunocompetentImmunologic ToleranceImmunologyImpairmentIn VitroIncidenceInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseIntercrinesInterleukin-8IntestinalIntestinal DiseasesIntestinal DisorderIntestinesInvestigationLarge IntestineLeukocyte Adhesion InhibitorLymphocyte-Derived Neutrophil-Activating PeptideMacrophage-Derived Chemotactic FactorMagnetismMetabolicMicrobeModelingModern ManMolecularMonocyte-Derived Neutrophil-Activating PeptideMonolayer cultureMucosaMucosal TissueMucous MembraneMucous body substanceMucusNeutrophil Activating PeptideNeutrophil Activation FactorNeutrophil Activation PeptideNeutrophil Chemotactic FactorOperative ProceduresOperative Surgical ProceduresOrganoidsPatientsPatternPeptidesPerforationPermeabilityPersonal SatisfactionPhysiologicPhysiologicalPhysiologyPolyanhydroglucuronic AcidPopulationPrevalenceProcessProductivityPropertyRemissionResearch SpecimenRoleSIS cytokinesSideSmall IntestinesSourceSpecimenStructureSubcellular ProcessSurfaceSurgicalSurgical InterventionsSurgical ProcedureSystemT4 CellsT4 LymphocytesTissue EngineeringTissuesTumor CellTumor Cell LineYouthYouth 10-21adulthoodalpha-Cellulosebio-engineeredbio-engineersbiobankbioengineered tissuebioengineeringbiological engineeringbiophysical foundationbiophysical principlesbiophysical sciencesbiorepositorybowelcare resource usecare resource utilizationcausationcell immortalizationcell typecellular differentiationchemoattractant cytokinechemokinechip modelchip systemcolon bacteriacolon disordercolonic bacteriacytokinedevelopmentaldietsdigestive disorderdigestive tract diseasedisabilitydisease causationdisease modeldisorder modeleleocolitisengineered tissuegastrointestinal stem cellgastrointestinal tract diseasegastrointestinal tract disordergut progenitorgut stem cellhealth care resource usehealth care resource utilizationhuman tissueiPSiPSCiPSCsimagingimmune competentimmune system toleranceimmune unresponsivenessimmunogenimmunological paralysisimmunoreactionimprovedin vitro Modelinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinflammatory disease of the intestineinflammatory disorder of the intestineinterdisciplinary collaborationintestinal autoinflammationintestinal epitheliumintestinal progenitorintestinal stem cellsintestine diseaseintestine disorderlarge bowelmagneticmatrigelmicrobial antigenmicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramicroorganism antigenmicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemminiaturizeminiaturizedmonolayermucousmultispecies consortianeoplastic cellnormal floranormal microbial floranormal microbiotanormal microfloranovelon a chipon chipregional enteritisscaffoldscaffoldingsmall bowelsocial rolespheroidsstemstoolsurgerytherapeutic targetthree dimensionaltransdisciplinary collaborationwell-beingwellbeingyouth age
Description preview
PROJECT SUMMARY/ABSTRACT
The goal of this proposal is to develop an ex vivo experimental platform to enable novel investigations into the
roles of the intestinal lumenal and basal microenvironment on the origins of Crohn's Disease (CD). CD is a
chronic, idiopathic inflammatory disease of the intestines whose incidence and prevalence are increasing…
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