grant
Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesions
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 19 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAssayBenignBioassayBiological AssayBiological MarkersBlood SerumBody TissuesCancersClinicClinicalClinical ChemistryClinical EvaluationClinical TestingComplexCyst FluidCystic NeoplasmCystic TumorDataData ScienceDevelopmentDiagnosticDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDiseaseDisorderDistantDistant CancerDistant MetastasisEDRNEarly Detection Research NetworkEarly DiagnosisEndoscopic UltrasonographyEvaluationGeneral PopulationGeneral PublicGoalsHistoryImageIndividualIndustryInvestigatorsLesionLocal CancerLocalized CancerLocalized MalignancyLocalized Malignant NeoplasmLow PrevalenceLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMethodsMolecularMorbidityMorbidity - disease rateMucinousMucinous NeoplasmMucinous TumorNational Detection Research NetworkNatureNumerical valueOperative ProceduresOperative Surgical ProceduresPancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreaticPancreatic CancerPancreatic Ductal AdenocarcinomaPapillaryPathologyPathway interactionsPatientsPhasePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrevalencePrimary NeoplasmPrimary TumorProcessPrognosisProtein ModificationProteinsProteomicsRecommendationRecording of previous eventsRegional DiseaseResearchResearch PersonnelResearch ResourcesResearch SpecimenResearchersResectedResourcesRiskSamplingScienceSerumSpecimenSurgicalSurgical InterventionsSurgical ProcedureSurvival RateSystemTechnologyTestingTissue BanksTissue CollectionTissue SampleTissue repositoryTissuesTranslationsUnresectableValidationalgorithm developmentassay developmentbio-markersbiobankbiologic markerbiomarkerbiomarker arraybiomarker developmentbiomarker panelbiomarker selectionbiorepositorycancer biomarkerscancer markerscandidate biomarkercandidate markercandidate selectionclinical developmentclinical diagnosticsclinical testdesigndesigningdevelopmentaldirect patient careearly biomarkersearly detectionearly detection biomarkersearly detection markersendoscopic ultrasoundhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhistoriesimagingin-vitro diagnosticsindexinginnovateinnovationinnovativelaser capture microdissectionlymph glandlymph nodeslymphnodesmachine statistical learningmalignancymarker panelmedical diagnosticmembermortalitymulti-modalitymultidisciplinarymultimodalityneoplasm/cancernew approachesnovel approachesnovel strategiesnovel strategypancreas developmentpancreatic malignancypathwayprecancerprecancerouspremalignantproteogenomicsresearch clinical testingscreeningscreeningsstatistical and machine learningsuccesssurgerysurveillance imagingtranslationtumorvalidations
Description preview
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with an overall 5-year survival
of 11%. Due to its asymptomatic nature and lack of methods for early detection, the majority of PDAC patients
(> 85%) present with non-localized tumors. This highlights the need to detect PDAC at an earlier, localized stage.
Intraductal…
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