grant
Development of a Novel Biomarker and PET Radiotracer for Specific Imaging of Microglial Responses
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAblationAddressAffinityAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimers DementiaAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnimal ModelAnimal Models and Related StudiesApoplexyAstrocytesAstrocytusAstrogliaAstroproteinAutopsyAutoradiographyBBB crossingBackground Potassium ChannelsBaseline Potassium ChannelsBeta Proprotein Interleukin 1BindingBiodistributionBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemBrain TraumaBrain Vascular AccidentCD68 antigenCNS Nervous SystemCd68Cell BodyCellsCentral Nervous SystemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChemicalsChemistryChronicClinicalDegenerative Neurologic DisordersDevelopmentDiagnosisDiseaseDisease ProgressionDisorderDisseminated SclerosisEncephalonEnsureEnvironmentEvaluationExhibitsF elementFluorineGFA-ProteinGFAPGehrig's DiseaseGeneticGliaGlial CellsGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsHalothaneHortega cellHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImageImaging DeviceImaging InstrumentImaging ToolImaging ligandsImmune Modulation TherapyImmune responseIn VitroInflammasomeInflammatoryInterleukin 1betaInterleukin-1 betaInterleukin-1βIntermediary MetabolismK channelKnowledgeKolliker's reticulumLabelLeadLeak Potassium ChannelsLibrariesLigandsLou Gehrig DiseaseMacrophageMeasuresMediatorMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaModelingModern ManMolecular InteractionMonitorMultiple SclerosisMurineMusMyeloid CellsMφNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuron DegenerationNeuronsNeurosciencesNon-neuronal cellNonneuronal cellPETPET ScanPET imagingPETSCANPETTParalysis AgitansParkinsonParkinson DiseasePathogenesisPb elementPenetrancePhagocytosisPhenotypePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPotassium ChannelPotassium Ion ChannelsPreinterleukin 1 BetaPrimary ParkinsonismPrimary Senile Degenerative DementiaProteinsRad.-PETRadioautographyRadiolabeledReaction TimeReportingResearchResponse RTResponse TimeRisk ReductionRodent ModelRoleSafetySensitivity and SpecificitySequence HomologySeriesSpecificityStrokeTandem Pore Domain K+ ChannelsTandem Pore Domain Potassium ChannelsTherapeuticTissuesTracerTranslational ResearchTranslational ScienceTraumatic Brain InjuryValidationWorkalzheimer modelamyloid pathologyastrocytic gliablood-brain barrier crossingbloodbrain barrier crossingbrain attackcerebral vascular accidentcerebrovascular accidentclinical diagnosisdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldisease riskdisorder riskgitter cellglial activationglial cell activationheavy metal Pbheavy metal leadhistologic stainshistological stainshost responseimagingimaging approachimaging based approachimaging biomarkerimaging markerimaging probeimaging-based biological markerimaging-based biomarkerimaging-based markerimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune-modulation treatmentimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimprovedin vivoinnovateinnovationinnovativeinsightinsular sclerosismesogliamicroglial cellmicrogliocytemodel of animalmouse modelmultidisciplinarymurine modelnecropsynerve cementneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneurological diseaseneuronalneuronal degenerationnew approachesnew markernovelnovel approachesnovel biomarkernovel markernovel strategiesnovel strategyperivascular glial cellpharmacologicpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempre-clinicalpreclinicalprimary degenerative dementiapsychomotor reaction timeradiolabelradiolabelingradiolabelsradioligandradiologically labeledradiotracerreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresponserisk-reducingscreeningscreeningssenile dementia of the Alzheimer typesmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolestrokedstrokestherapeutic immunomodulationtherapeutic immunoregulationtherapeutic targettooltranslation researchtranslational investigationtraumatic brain damageuptakevalidations
Description preview
Project Summary/Abstract
Chronic microglial activation is an early and critical driver of neurodegenerative diseases. Hence, there is an
urgent need to measure microglial responses in vivo. Positron emission tomography (PET) provides a non-
invasive means to track and quantify microglial responses. However, current approaches are limited by the…
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