Development of a Direct Diagnostic Test for Infectious and Congenital Syphilis
Full Description
PROJECT SUMMARY
Current diagnostic tests for syphilis are non-optimal, in that they cannot differentiate active from past
infection, cannot diagnose congenital syphilis, and have low sensitivity in early and late disease. With
the number of infectious and congenital syphilis cases rapidly expanding in the US and worldwide,
curbing the spread of disease will be aided by development of a better diagnostic test that is definitive,
easily interpreted, and compatible with a point-of-care test format. In this research application we
propose to develop a direct syphilis diagnostic test that: (1) exhibits high sensitivity and specificity at all
disease stages; (2) can differentiate active versus past infections; (3) can differentiate syphilis from
yaws; (4) can allow accurate disease staging; and (5) can be adapted to a point-of-care format for ease
of testing in remote areas.
Grant Number: 5R21AI186005-02
NIH Institute/Center: NIH
Principal Investigator: CAROLINE CAMERON
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