grant
Development and validation of a predictor of meningioma recurrence
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AbscissionAddressAdjuvantAdjuvant RadiotherapyBehaviorBiologyCell CycleCell Division CycleCessation of lifeClassificationClinicalDNADNA MethylationDNA mutationDataData DiscoveryDeathDedicationsDeoxyribonucleic AcidDevelopmentExcisionExhibitsExtirpationGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsHeterogeneityImmunomodulationInternationalIntracranial Central Nervous System NeoplasmsIntracranial Central Nervous System TumorsIntracranial NeoplasmsIntracranial TumorLearningMachine LearningMacrophageMerlinMetabolic PathwayMethodsMethylationMoesin-Ezrin-Radixin-Like ProteinMolecularMultiomic DataMutationMφNF2NF2 Gene ProductNF2 geneNetwork AnalysisNeurofibromatosis 2 Gene ProductNeurofibromatosis 2 GenesNeurofibromatosis Type 2 ProteinNeurofibromin 2NomogramsNon-Polyadenylated RNAOperative ProceduresOperative Surgical ProceduresOutcomePathway AnalysisPathway interactionsPatient SelectionPatientsProgression-Free SurvivalsRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqRadiationRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRemovalRibonucleic AcidSchwannomerlinSchwannominSchwannomin ProteinSubgroupSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSystematicsTrainingTumor CellUpregulationValidationadjuvant radiation therapybiological heterogeneitycancer progressionclinical heterogeneitycohortdevelopmentalepigenomeexome sequencingexome-seqexperiencegenome mutationimmune modulationimmune regulationimmunogenicimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryindividual patientmachine based learningmeningiomamethylomemultiple omic dataneoplasm progressionneoplasm recurrenceneoplastic cellneoplastic progressionnf 2 Genespathwaypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpreventpreventingprogramsprospectiveresectionstandard of caresurgerytranscriptome sequencingtranscriptomic sequencingtumortumor progressionvalidations
Description preview
Meningiomas exhibit considerable clinical and biological heterogeneity. We previously identified 4 distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, and proliferative) that address much of this heterogeneity. Despite the utility of these groups, the stochasticity of clustering methods and the use of multi-omics data for…
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